Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array

R. Harouaka; X. Liu; W. Khan; T. Khan; S. Rice; C. Belani; S. Y. Zheng

Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array

R. Harouaka
, X. Liu
, W. Khan
, T. Khan
, S. Rice
, C. Belani
, S. Y. Zheng

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Circulating tumor cells (CTCs) in peripheral blood are implicated in the spread of cancer by metastasis. CTCs are associated with worse survival and have been demonstrated as a prognostic biomarker in various cancer types. We have developed a flexible micro spring array (FMSA) device for antigen-independent viable-enrichment of CTCs from whole blood based on cell size and deformability. CTCs were enriched from twenty blood samples obtained from advanced non-small cell lung cancer (NSCLC) patients and quantified through immunocytochemical detection. CTC detection was correlated to a significant decrease in patient survival demonstrating the clinical relevance of FMSA-enriched CTCs in NSCLC.

Original language	English (US)
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	579-581
Number of pages	3
ISBN (Electronic)	9780979806476
State	Published - 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: Oct 26 2014 → Oct 30 2014

Publication series

Name	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	10/26/14 → 10/30/14

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Control and Systems Engineering

Cite this

Harouaka, R., Liu, X., Khan, W., Khan, T., Rice, S., Belani, C., & Zheng, S. Y. (2014). Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 579-581). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.

Harouaka, R. ; Liu, X. ; Khan, W. et al. / Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 579-581 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

@inproceedings{d06be08a269b4750b3afc8cbf0ca9f5c,

title = "Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array",

abstract = "Circulating tumor cells (CTCs) in peripheral blood are implicated in the spread of cancer by metastasis. CTCs are associated with worse survival and have been demonstrated as a prognostic biomarker in various cancer types. We have developed a flexible micro spring array (FMSA) device for antigen-independent viable-enrichment of CTCs from whole blood based on cell size and deformability. CTCs were enriched from twenty blood samples obtained from advanced non-small cell lung cancer (NSCLC) patients and quantified through immunocytochemical detection. CTC detection was correlated to a significant decrease in patient survival demonstrating the clinical relevance of FMSA-enriched CTCs in NSCLC.",

author = "R. Harouaka and X. Liu and W. Khan and T. Khan and S. Rice and C. Belani and Zheng, \{S. Y.\}",

note = "Publisher Copyright: {\textcopyright} 14CBMS.; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

year = "2014",

language = "English (US)",

series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

publisher = "Chemical and Biological Microsystems Society",

pages = "579--581",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

}

Harouaka, R, Liu, X, Khan, W, Khan, T, Rice, S, Belani, C & Zheng, SY 2014, Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society, pp. 579-581, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 10/26/14.

Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array. / Harouaka, R.; Liu, X.; Khan, W. et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 579-581 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array

AU - Harouaka, R.

AU - Liu, X.

AU - Khan, W.

AU - Khan, T.

AU - Rice, S.

AU - Belani, C.

AU - Zheng, S. Y.

PY - 2014

Y1 - 2014

N2 - Circulating tumor cells (CTCs) in peripheral blood are implicated in the spread of cancer by metastasis. CTCs are associated with worse survival and have been demonstrated as a prognostic biomarker in various cancer types. We have developed a flexible micro spring array (FMSA) device for antigen-independent viable-enrichment of CTCs from whole blood based on cell size and deformability. CTCs were enriched from twenty blood samples obtained from advanced non-small cell lung cancer (NSCLC) patients and quantified through immunocytochemical detection. CTC detection was correlated to a significant decrease in patient survival demonstrating the clinical relevance of FMSA-enriched CTCs in NSCLC.

AB - Circulating tumor cells (CTCs) in peripheral blood are implicated in the spread of cancer by metastasis. CTCs are associated with worse survival and have been demonstrated as a prognostic biomarker in various cancer types. We have developed a flexible micro spring array (FMSA) device for antigen-independent viable-enrichment of CTCs from whole blood based on cell size and deformability. CTCs were enriched from twenty blood samples obtained from advanced non-small cell lung cancer (NSCLC) patients and quantified through immunocytochemical detection. CTC detection was correlated to a significant decrease in patient survival demonstrating the clinical relevance of FMSA-enriched CTCs in NSCLC.

UR - https://www.scopus.com/pages/publications/84941662910

UR - https://www.scopus.com/pages/publications/84941662910#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:84941662910

T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

SP - 579

EP - 581

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

Harouaka R, Liu X, Khan W, Khan T, Rice S, Belani C et al. Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society. 2014. p. 579-581. (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array

Abstract

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UN SDGs

All Science Journal Classification (ASJC) codes

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