@article{eb62f5ead08f4c539cbd028ec27f2e48,
title = "Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels",
abstract = "Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose‐, blood‐, and cellulose‐derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.",
author = "Trivia Frazier and Andrea Alarcon and Xiying Wu and Mohiuddin, {Omair A.} and Motherwell, {Jessica M.} and Carlsson, {Anders H.} and Christy, {Robert J.} and Edwards, {Judson V.} and Mackin, {Robert T.} and Nicolette Prevost and Elena Gloster and Qiang Zhang and Guangdi Wang and Hayes, {Daniel J.} and Gimble, {Jeffrey M.}",
note = "Funding Information: Conflicts of Interest: Ms. Alarcon is an employee of Obatala Sciences. Drs. Frazier, Wu, and Gimble are co‐ founders, co‐owners, and officers at Obatala Sciences, a biotech company focused on regenerative medicine, and are inventors of patents with technology related to the content of the manuscript. Drs. Wu and Gimble are also co‐founders and co‐owners of LaCell LLC and Talaria Antibodies Inc. Dr. Wang is the founder, owner, and CEO of Zenopharm LLC, a pharmaceutical discovery company. The views expressed in this article are those of the authors and do not reflect the official policy or position of the U.S. Army Medical Department, Department of the Army, DoD, or the U.S. Government. This publication was made possible by NIH Grant Number U54MD007595 from the National Institute of Minority Health and Health Disparities. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Funding Information: Funding: This research was funded by Major Instrument Core (funded by RCMI-NIH grant U54MD007595) at Xavier University LA for LC-MS based proteomic analysis. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = oct,
doi = "10.3390/biom10101373",
language = "English (US)",
volume = "10",
pages = "1--21",
journal = "Biomolecules",
issn = "2218-273X",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",
}