Clinicoepidemiological features and mortality analysis of deceased patients with COVID-19 in a tertiary care centre

Richa Aggarwal, Ridhima Bhatia, Kshitija Kulshrestha, Kapil D. Soni, Renjith Viswanath, Ashutosh K. Singh, Karthik V. Iyer, Puneet Khanna, Sulagna Bhattacharjee, Nishant Patel, Ajisha Aravindan, Anju Gupta, Yudhyavir Singh, Venkata Ganesh, Rakesh Kumar, Arshed Ayub, Shailender Kumar, Kellika Prakash, Vineeta Venkateswaran, Debesh BhoiManish Soneja, Purva Mathur, Rajesh Malhotra, Naveet Wig, Randeep Guleria, Anjan Trikha

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9 Scopus citations

Abstract

Background and objective: A large number of studies describing the clinicoepidemological features of coronavirus disease 2019 (COVID-19) patients are available but very few studies have documented similar features of the deceased. This study was aimed to describe the clinicoepidemological features and the causes of mortality of COVID-19 deceased patients admitted in a dedicated COVID center in India. Methodology: This was a retrospective study done in adult deceased patients admitted in COVID ICU from April 4 to July 24, 2020. The clinical features, comorbidities, complications, and causes of mortality in these patients were analyzed. Pediatric deceased were analyzed separately. Results: A total of 654 adult patients were admitted in the ICU during the study period and ICU mortality was 37.7% (247/654). Among the adult deceased, 65.9% were males with a median age of 56 years [interquartile range (IQR), 41.5–65] and 94.74% had one or more comorbidities, most common being hypertension (43.3%), diabetes mellitus (34.8%), and chronic kidney disease (20.6%). The most common presenting features in these deceased were fever (75.7%), cough (68.8%), and shortness of breath (67.6%). The mean initial sequential organ failure assessment score was 9.3 ± 4.7 and 24.2% were already intubated at the time of admission. The median duration of hospital stay was 6 days (IQR, 3–11). The most common cause of death was sepsis with multiorgan failure (55.1%) followed by severe acute respiratory distress syndrome (ARDS) (25.5%). All pediatric deceased had comorbid conditions and the most common cause of death in this group was severe ARDS. Conclusion: In this cohort of adult deceased, most were young males with age less than 65 years with one or more comorbidities, hypertension being the most common. Only 5% of the deceased had no comorbidities. Sepsis with multiorgan dysfunction syndrome was the commonest cause of death.

Original languageEnglish (US)
Pages (from-to)622-628
Number of pages7
JournalIndian Journal of Critical Care Medicine
Volume25
Issue number6
DOIs
StatePublished - Jun 2021

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

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