TY - JOUR
T1 - Clonazepam
T2 - Sleep laboratory study of efficacy and withdrawal
AU - Kales, Anthony
AU - Manfredi, Rocco L.
AU - Vgontzas, Alexandros N.
AU - Baldassano, Claudia F.
AU - Kostakos, Katherine
AU - Kales, Joyce D.
PY - 1991/6
Y1 - 1991/6
N2 - Clonazepam 0.5 mg was evaluated in a sleep laboratory study of 6 insomniac patients. The 16-night protocol consisted of 4 placebo-baseline nights, 7 nights of drug administration and 5 placebo-with-drawal nights. Clonazepam produced a significant decrease in total wake time initially (nights 5–7), as well as with continued administration (nights 9–11). With later but not immediate withdrawal, significant rebound insomnia occurred, on the 3rd withdrawal night, both wake time after sleep onset and total wake time increased markedly, with the latter significantly increased. These findings are discussed in light of clonazepam’s increasing use for panic disorder; specifically, due to its maintained efficacy, it has the advantage of avoiding interdose rebound anxiety which is frequently reported with use of alprazolam.
AB - Clonazepam 0.5 mg was evaluated in a sleep laboratory study of 6 insomniac patients. The 16-night protocol consisted of 4 placebo-baseline nights, 7 nights of drug administration and 5 placebo-with-drawal nights. Clonazepam produced a significant decrease in total wake time initially (nights 5–7), as well as with continued administration (nights 9–11). With later but not immediate withdrawal, significant rebound insomnia occurred, on the 3rd withdrawal night, both wake time after sleep onset and total wake time increased markedly, with the latter significantly increased. These findings are discussed in light of clonazepam’s increasing use for panic disorder; specifically, due to its maintained efficacy, it has the advantage of avoiding interdose rebound anxiety which is frequently reported with use of alprazolam.
UR - http://www.scopus.com/inward/record.url?scp=0025828427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025828427&partnerID=8YFLogxK
M3 - Article
C2 - 2066457
AN - SCOPUS:0025828427
SN - 0271-0749
VL - 11
SP - 189
EP - 193
JO - Journal of Clinical Psychopharmacology
JF - Journal of Clinical Psychopharmacology
IS - 3
ER -