Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

Harry Mellor; Kevin M. Flowers; Scot R. Kimball; Leonard S. Jefferson

doi:10.1016/0167-4781(94)90229-1

Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

Harry Mellor, Kevin M. Flowers, Scot R. Kimball, Leonard S. Jefferson

Department of Cellular and Molecular Physiology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We have isolated and sequenced a full-length cDNA encoding the double-stranded RNA-dependent protein kinase PKR from rat. The derived amino acid sequences of the protein kinase and RNA-binding domains are highly conserved between the rat, human and mouse enzymes. In addition, sequence elements in the 5′- and 3′-untranslated regions are also conserved between species.

Original language	English (US)
Pages (from-to)	693-696
Number of pages	4
Journal	BBA - Gene Structure and Expression
Volume	1219
Issue number	3
DOIs	https://doi.org/10.1016/0167-4781(94)90229-1
State	Published - Nov 22 1994

All Science Journal Classification (ASJC) codes

Structural Biology
Biophysics
Biochemistry
Genetics

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abstract = "We have isolated and sequenced a full-length cDNA encoding the double-stranded RNA-dependent protein kinase PKR from rat. The derived amino acid sequences of the protein kinase and RNA-binding domains are highly conserved between the rat, human and mouse enzymes. In addition, sequence elements in the 5′- and 3′-untranslated regions are also conserved between species.",

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AU - Flowers, Kevin M.

AU - Kimball, Scot R.

AU - Jefferson, Leonard S.

PY - 1994/11/22

Y1 - 1994/11/22

N2 - We have isolated and sequenced a full-length cDNA encoding the double-stranded RNA-dependent protein kinase PKR from rat. The derived amino acid sequences of the protein kinase and RNA-binding domains are highly conserved between the rat, human and mouse enzymes. In addition, sequence elements in the 5′- and 3′-untranslated regions are also conserved between species.

AB - We have isolated and sequenced a full-length cDNA encoding the double-stranded RNA-dependent protein kinase PKR from rat. The derived amino acid sequences of the protein kinase and RNA-binding domains are highly conserved between the rat, human and mouse enzymes. In addition, sequence elements in the 5′- and 3′-untranslated regions are also conserved between species.

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ER -

Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

Abstract

All Science Journal Classification (ASJC) codes

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