Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

Harry Mellor, Kevin M. Flowers, Scot R. Kimball, Leonard S. Jefferson

    Research output: Contribution to journalArticlepeer-review

    24 Scopus citations

    Abstract

    We have isolated and sequenced a full-length cDNA encoding the double-stranded RNA-dependent protein kinase PKR from rat. The derived amino acid sequences of the protein kinase and RNA-binding domains are highly conserved between the rat, human and mouse enzymes. In addition, sequence elements in the 5′- and 3′-untranslated regions are also conserved between species.

    Original languageEnglish (US)
    Pages (from-to)693-696
    Number of pages4
    JournalBBA - Gene Structure and Expression
    Volume1219
    Issue number3
    DOIs
    StatePublished - Nov 22 1994

    All Science Journal Classification (ASJC) codes

    • Structural Biology
    • Biophysics
    • Biochemistry
    • Genetics

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