Co-relationship of physical stability of amorphous dispersions with enthalpy relaxation

S. S. Bansal; A. M. Kaushal; Arvind K. Bansal

doi:10.1691/ph.2008.7399

Co-relationship of physical stability of amorphous dispersions with enthalpy relaxation

S. S. Bansal, A. M. Kaushal, Arvind K. Bansal

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10 Scopus citations

Abstract

Physical stability studies of valdecoxib (VLB) and its solid dispersions with PVP (1, 2, 5, 10, 15 and 20% w/w) were carried out by Differential Scanning Calorimetry (DSC). Change in specific heat with time was measured to determine the degree of crystallinity of amorphous drug and its binary dispersions after storage at 40°C and 75% RH. The rate of crystallization was found to decrease with increasing PVP concentration and time for 10% crystallization (t_90%) was found to increase significantly for the amorphous drug when formulated as PVP dispersions. Enthalpy relaxation was found to be inversely correlated with t_90% (min) values and was found to be a good predictor of devitrification tendency and hence stability of amorphous VLB.

Original language	English (US)
Pages (from-to)	812-814
Number of pages	3
Journal	Pharmazie
Volume	63
Issue number	11
DOIs	https://doi.org/10.1691/ph.2008.7399
State	Published - Nov 2008

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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10.1691/ph.2008.7399

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title = "Co-relationship of physical stability of amorphous dispersions with enthalpy relaxation",

abstract = "Physical stability studies of valdecoxib (VLB) and its solid dispersions with PVP (1, 2, 5, 10, 15 and 20% w/w) were carried out by Differential Scanning Calorimetry (DSC). Change in specific heat with time was measured to determine the degree of crystallinity of amorphous drug and its binary dispersions after storage at 40°C and 75% RH. The rate of crystallization was found to decrease with increasing PVP concentration and time for 10% crystallization (t90%) was found to increase significantly for the amorphous drug when formulated as PVP dispersions. Enthalpy relaxation was found to be inversely correlated with t90% (min) values and was found to be a good predictor of devitrification tendency and hence stability of amorphous VLB.",

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year = "2008",

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AU - Bansal, S. S.

AU - Kaushal, A. M.

AU - Bansal, Arvind K.

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Y1 - 2008/11

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AB - Physical stability studies of valdecoxib (VLB) and its solid dispersions with PVP (1, 2, 5, 10, 15 and 20% w/w) were carried out by Differential Scanning Calorimetry (DSC). Change in specific heat with time was measured to determine the degree of crystallinity of amorphous drug and its binary dispersions after storage at 40°C and 75% RH. The rate of crystallization was found to decrease with increasing PVP concentration and time for 10% crystallization (t90%) was found to increase significantly for the amorphous drug when formulated as PVP dispersions. Enthalpy relaxation was found to be inversely correlated with t90% (min) values and was found to be a good predictor of devitrification tendency and hence stability of amorphous VLB.

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Co-relationship of physical stability of amorphous dispersions with enthalpy relaxation

Abstract

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