Abstract
Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.
Original language | English (US) |
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Pages (from-to) | 2757-2760 |
Number of pages | 4 |
Journal | Endocrinology |
Volume | 144 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2003 |
All Science Journal Classification (ASJC) codes
- Endocrinology