Cold sensory transduction through the STIM-Orai signaling pathway

Yandong Zhou, Michelle R. Jennette, Donald L. Gill

Research output: Contribution to journalComment/debatepeer-review


The STIM-Orai signaling pathway mediates Ca2+ signals vital for controlling transcription and cell growth. The Ca2+ sensing STIM proteins are activated by depletion of Ca2+ stored in the ER, and translocate into ER-PM junctions to gate PM Orai channels. STIM1 activation also results from heating STIM1 proteins, and new evidence reveals the STIM1-mediated gating of Orai1 channels is activated by noxious cooling of cells. This activation of the STIM-Orai pathway may be important in mediating vascular dilation that occurs in response to severe cold exposure.

Original languageEnglish (US)
Article number102735
JournalCell Calcium
StatePublished - Jun 2023

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology


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