Collaborative routes to clarifying the murky waters of aqueous supramolecular chemistry

Paul S. Cremer, Amar H. Flood, Bruce C. Gibb, David L. Mobley

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations


On planet Earth, water is everywhere: The majority of the surface is covered with it; it is a key component of all life; its vapour and droplets fill the lower atmosphere; and even rocks contain it and undergo geomorphological changes because of it. A community of physical scientists largely drives studies of the chemistry of water and aqueous solutions, with expertise in biochemistry, spectroscopy and computer modelling. More recently, however, supramolecular chemists-with their expertise in macrocyclic synthesis and measuring supramolecular interactions-have renewed their interest in water-mediated non-covalent interactions. These two groups offer complementary expertise that, if harnessed, offer to accelerate our understanding of aqueous supramolecular chemistry and water writ large. This Review summarizes the state-of-the-art of the two fields, and highlights where there is latent chemical space for collaborative exploration by the two groups.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalNature Chemistry
Issue number1
StatePublished - Dec 19 2017

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering


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