TY - JOUR
T1 - Combating mosquito-borne diseases using genetic control technologies
AU - Wang, Guan Hong
AU - Gamez, Stephanie
AU - Raban, Robyn R.
AU - Marshall, John M.
AU - Alphey, Luke
AU - Li, Ming
AU - Rasgon, Jason L.
AU - Akbari, Omar S.
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control.
AB - Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control.
UR - http://www.scopus.com/inward/record.url?scp=85110831200&partnerID=8YFLogxK
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U2 - 10.1038/s41467-021-24654-z
DO - 10.1038/s41467-021-24654-z
M3 - Review article
C2 - 34282149
AN - SCOPUS:85110831200
SN - 2041-1723
VL - 12
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 4388
ER -