Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

S. K. Misra; X. Wang; I. Srivastava; M. K. Imgruet; R. W. Graff; A. Ohoka; T. L. Kampert; H. Gao; D. Pan

doi:10.1039/c5cc07709e

Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

S. K. Misra, X. Wang, I. Srivastava, M. K. Imgruet, R. W. Graff, A. Ohoka, T. L. Kampert, H. Gao, D. Pan

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6-20 times more selective than the parent drugs.

Original language	English (US)
Pages (from-to)	16710-16713
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	93
DOIs	https://doi.org/10.1039/c5cc07709e
State	Published - 2015

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c5cc07709e

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abstract = "We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6-20 times more selective than the parent drugs.",

author = "Misra, {S. K.} and X. Wang and I. Srivastava and Imgruet, {M. K.} and Graff, {R. W.} and A. Ohoka and Kampert, {T. L.} and H. Gao and D. Pan",

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AU - Misra, S. K.

AU - Wang, X.

AU - Srivastava, I.

AU - Imgruet, M. K.

AU - Graff, R. W.

AU - Ohoka, A.

AU - Kampert, T. L.

AU - Gao, H.

AU - Pan, D.

PY - 2015

Y1 - 2015

N2 - We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6-20 times more selective than the parent drugs.

AB - We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6-20 times more selective than the parent drugs.

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Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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