TY - JOUR
T1 - Combined epidural-general anaesthesia vs general anaesthesia in neonatal gastrointestinal surgery
T2 - A randomized controlled trial
AU - Gannam-Somri, Lina
AU - Matter, Ibrahim
AU - Hadjittofi, Christopher
AU - Vaida, Sonia
AU - Khalaily, Husein
AU - Hossein, Jalaa
AU - Somri, Mostafa
N1 - Publisher Copyright:
© 2019 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Background: Post-operative ileus is a frequent complication of gastrointestinal surgery under general anaesthesia. The aim of this study was to investigate whether combined epidural-general anaesthesia is associated with expedited gastrointestinal function recovery in neonates undergoing elective gastrointestinal surgery. Methods: A randomized controlled trial including 60 neonates who underwent gastrointestinal surgery at a university hospital was performed. Thirty neonates received combined epidural-general anaesthesia (CEGA), and 30 neonates received general anaesthesia (GA) alone. The primary outcome was the post-operative time to tolerance of full enteral nutrition. The secondary outcomes were the post-operative time defaecation, the duration of nasogastric drainage, and infections. Results: After excluding two neonates from the CEGA group, where repeated attempts at epidural catheterization were unsuccessful, a total of 58 patients completed the study (CEGA: 28; GA: 30). Full enteral nutrition was tolerated earlier in CEGA vs the GA group (4.0 vs 8.0 days; P =.0001). Time to defaecation was shorter in the CEGA group (3.5 vs 5.0 days; P =.0001). Duration of nasogastric drainage was similar between groups (7.0 vs 7.0 days; P =.9502). Fewer patients in the CEGA group experienced post-operative infection (35.7% vs 60.0%; P =.038). Conclusion: Combined epidural-general anaesthesia is associated with expedited gastrointestinal function recovery and a lower infection risk after gastrointestinal surgery in neonates.
AB - Background: Post-operative ileus is a frequent complication of gastrointestinal surgery under general anaesthesia. The aim of this study was to investigate whether combined epidural-general anaesthesia is associated with expedited gastrointestinal function recovery in neonates undergoing elective gastrointestinal surgery. Methods: A randomized controlled trial including 60 neonates who underwent gastrointestinal surgery at a university hospital was performed. Thirty neonates received combined epidural-general anaesthesia (CEGA), and 30 neonates received general anaesthesia (GA) alone. The primary outcome was the post-operative time to tolerance of full enteral nutrition. The secondary outcomes were the post-operative time defaecation, the duration of nasogastric drainage, and infections. Results: After excluding two neonates from the CEGA group, where repeated attempts at epidural catheterization were unsuccessful, a total of 58 patients completed the study (CEGA: 28; GA: 30). Full enteral nutrition was tolerated earlier in CEGA vs the GA group (4.0 vs 8.0 days; P =.0001). Time to defaecation was shorter in the CEGA group (3.5 vs 5.0 days; P =.0001). Duration of nasogastric drainage was similar between groups (7.0 vs 7.0 days; P =.9502). Fewer patients in the CEGA group experienced post-operative infection (35.7% vs 60.0%; P =.038). Conclusion: Combined epidural-general anaesthesia is associated with expedited gastrointestinal function recovery and a lower infection risk after gastrointestinal surgery in neonates.
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U2 - 10.1111/aas.13469
DO - 10.1111/aas.13469
M3 - Article
C2 - 31506919
AN - SCOPUS:85073981186
SN - 0001-5172
VL - 64
SP - 34
EP - 40
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
IS - 1
ER -