Combined Merkel cell carcinoma and atypical fibroxanthoma

Summer R. Youker, Elizabeth M. Billingsley

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background: Although there are reports of squamous cell carcinoma arising within and adjacent to Merkel cell carcinoma, and one report of an atypical fibroxanthoma-like tumor arising in an irradiated recurrent Merkel cell carcinoma, there have previously been no reports of an immunohistochemically verified atypical fibroxanthoma occurring in conjunction with a Merkel cell carcinoma. Objective: We report on a neoplasm with distinct features of both Merkel cell carcinoma and atypical fibroxanthoma. Methods: Histologic and immunohistochemical evaluations were performed. Results: Our results verify the finding of a combined Merkel cell carcinoma and atypical fibroxanthoma. Conclusion: This case is an interesting and unusual combination of tumors. The origin of the Merkel cell carcinoma is revisited. Debated origins include neuroendocrine, epithelial, and pleuripotent stem cell.

Original languageEnglish (US)
Pages (from-to)6-9
Number of pages4
JournalJournal of Cutaneous Medicine and Surgery
Issue number1
StatePublished - Feb 1 2005

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology


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