Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse Cu, Zn superoxide dismutase mutants

Keyphrases

• Amyotrophic Lateral Sclerosis 100%
• Superoxide Dismutase 1 (SOD1) 100%
• Dynamical Signature 100%
• Zn-superoxide Dismutase 100%
• Coupled Motion 66%
• Metal Binding 33%
• Dimer Interface 33%
• Molecular Dynamics Simulation 16%
• Point mutation 16%
• In the Wild 16%
• Mutation Effect 16%
• Long-distance Communication 16%
• Protein Stability 16%
• Dynamic Coupling 16%
• Protein Dynamics 16%
• Common Effects 16%
• Altered Proteins 16%
• High Connectivity 16%
• Deprotection 16%
• Dimer Dissociation 16%
• Breathing Motion 16%
• Mutant SOD1 16%

Biochemistry, Genetics and Molecular Biology

• Superoxide Dismutase 100%
• SOD1 100%
• Motion 85%
• Wild Type 28%
• Metal Binding 28%
• Enzyme 14%
• Point Mutation 14%
• Breathing 14%
• Induced Mutation 14%
• Protein Stability 14%