Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats

Ali Ahiskalioglu, Ilker Ince, Mehmet Aksoy, Elif Oral Ahiskalioglu, Mehmet Comez, Aysenur Dostbil, Mine Celik, Hamit Hakan Alp, Resit Coskun, Ali Taghizadehghalehjoughi, Bahadir Suleyman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) on single dose ketamine (60 mg/kg)-induced cardiotoxicity. In group B, we investigated the effect of metyrosine and metoprolol, which were given together with ketamine for 30 days. In group C, we investigated the effect of metyrosine and metoprolol given 15 days before ketamine and 30 days together with ketamine on ketamine cardiotoxicity. By the end of this process, we evaluated the effects of the levels of oxidant–antioxidant parameters such as MDA, MPO, 8-OHGua, tGSH, and SOD in addition to CK-MB and TP I on cardiotoxicity in rat heart tissue. The experimental results show that metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C.

Original languageEnglish (US)
Pages (from-to)336-344
Number of pages9
JournalCardiovascular toxicology
Volume15
Issue number4
DOIs
StatePublished - Oct 26 2015

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

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