TY - JOUR
T1 - Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats
AU - Ahiskalioglu, Ali
AU - Ince, Ilker
AU - Aksoy, Mehmet
AU - Ahiskalioglu, Elif Oral
AU - Comez, Mehmet
AU - Dostbil, Aysenur
AU - Celik, Mine
AU - Alp, Hamit Hakan
AU - Coskun, Resit
AU - Taghizadehghalehjoughi, Ali
AU - Suleyman, Bahadir
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2015/10/26
Y1 - 2015/10/26
N2 - This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) on single dose ketamine (60 mg/kg)-induced cardiotoxicity. In group B, we investigated the effect of metyrosine and metoprolol, which were given together with ketamine for 30 days. In group C, we investigated the effect of metyrosine and metoprolol given 15 days before ketamine and 30 days together with ketamine on ketamine cardiotoxicity. By the end of this process, we evaluated the effects of the levels of oxidant–antioxidant parameters such as MDA, MPO, 8-OHGua, tGSH, and SOD in addition to CK-MB and TP I on cardiotoxicity in rat heart tissue. The experimental results show that metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C.
AB - This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) on single dose ketamine (60 mg/kg)-induced cardiotoxicity. In group B, we investigated the effect of metyrosine and metoprolol, which were given together with ketamine for 30 days. In group C, we investigated the effect of metyrosine and metoprolol given 15 days before ketamine and 30 days together with ketamine on ketamine cardiotoxicity. By the end of this process, we evaluated the effects of the levels of oxidant–antioxidant parameters such as MDA, MPO, 8-OHGua, tGSH, and SOD in addition to CK-MB and TP I on cardiotoxicity in rat heart tissue. The experimental results show that metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C.
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U2 - 10.1007/s12012-014-9301-z
DO - 10.1007/s12012-014-9301-z
M3 - Article
C2 - 25503950
AN - SCOPUS:84942371683
SN - 1530-7905
VL - 15
SP - 336
EP - 344
JO - Cardiovascular toxicology
JF - Cardiovascular toxicology
IS - 4
ER -