Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation

Steven J. Frank; Pierre Blanchard; J. Jack Lee; Erich M. Sturgis; Merrill S. Kies; Mitchell Machtay; Bhadrasain Vikram; Adam S. Garden; David I. Rosenthal; G. Brandon Gunn; C. David Fuller; Katherine Hutcheson; Stephen Lai; Paul M. Busse; Nancy Y. Lee; Alexander Lin; Robert L. Foote

doi:10.1016/j.semradonc.2017.12.002

Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation

Steven J. Frank, Pierre Blanchard, J. Jack Lee, Erich M. Sturgis, Merrill S. Kies, Mitchell Machtay, Bhadrasain Vikram, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, C. David Fuller, Katherine Hutcheson, Stephen Lai, Paul M. Busse, Nancy Y. Lee, Alexander Lin, Robert L. Foote

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Intensity-modulated proton therapy minimizes the incidental irradiation of normal tissues in patients with head and neck cancer relative to intensity-modulated photon (x-ray) therapy and has been associated with lesser treatment-related toxicity and improved quality of life. A phase II/III randomized trial sponsored by the US National Cancer Institute is currently underway to compare deintensification treatment strategies with intensity-modulated proton therapy vs intensity-modulated photon (x-ray) therapy for patients with advanced-stage oropharyngeal tumors. After significant input from numerous stakeholders, the phase III portion of the randomized trial was redesigned as a noninferiority trial with progression-free survival as the primary endpoint. The process by which that redesign took place is described here.

Original language	English (US)
Pages (from-to)	108-113
Number of pages	6
Journal	Seminars in Radiation Oncology
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.semradonc.2017.12.002
State	Published - Apr 2018

All Science Journal Classification (ASJC) codes

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semradonc.2017.12.002

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Frank, S. J., Blanchard, P., Lee, J. J., Sturgis, E. M., Kies, M. S., Machtay, M., Vikram, B., Garden, A. S., Rosenthal, D. I., Gunn, G. B., Fuller, C. D., Hutcheson, K., Lai, S., Busse, P. M., Lee, N. Y., Lin, A., & Foote, R. L. (2018). Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation. Seminars in Radiation Oncology, 28(2), 108-113. https://doi.org/10.1016/j.semradonc.2017.12.002

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title = "Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation",

abstract = "Intensity-modulated proton therapy minimizes the incidental irradiation of normal tissues in patients with head and neck cancer relative to intensity-modulated photon (x-ray) therapy and has been associated with lesser treatment-related toxicity and improved quality of life. A phase II/III randomized trial sponsored by the US National Cancer Institute is currently underway to compare deintensification treatment strategies with intensity-modulated proton therapy vs intensity-modulated photon (x-ray) therapy for patients with advanced-stage oropharyngeal tumors. After significant input from numerous stakeholders, the phase III portion of the randomized trial was redesigned as a noninferiority trial with progression-free survival as the primary endpoint. The process by which that redesign took place is described here.",

author = "Frank, {Steven J.} and Pierre Blanchard and Lee, {J. Jack} and Sturgis, {Erich M.} and Kies, {Merrill S.} and Mitchell Machtay and Bhadrasain Vikram and Garden, {Adam S.} and Rosenthal, {David I.} and Gunn, {G. Brandon} and Fuller, {C. David} and Katherine Hutcheson and Stephen Lai and Busse, {Paul M.} and Lee, {Nancy Y.} and Alexander Lin and Foote, {Robert L.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

month = apr,

doi = "10.1016/j.semradonc.2017.12.002",

language = "English (US)",

volume = "28",

pages = "108--113",

journal = "Seminars in Radiation Oncology",

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Frank, SJ, Blanchard, P, Lee, JJ, Sturgis, EM, Kies, MS, Machtay, M, Vikram, B, Garden, AS, Rosenthal, DI, Gunn, GB, Fuller, CD, Hutcheson, K, Lai, S, Busse, PM, Lee, NY, Lin, A & Foote, RL 2018, 'Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation', Seminars in Radiation Oncology, vol. 28, no. 2, pp. 108-113. https://doi.org/10.1016/j.semradonc.2017.12.002

Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation. / Frank, Steven J.; Blanchard, Pierre; Lee, J. Jack et al.
In: Seminars in Radiation Oncology, Vol. 28, No. 2, 04.2018, p. 108-113.

Research output: Contribution to journal › Review article › peer-review

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AU - Sturgis, Erich M.

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AU - Machtay, Mitchell

AU - Vikram, Bhadrasain

AU - Garden, Adam S.

AU - Rosenthal, David I.

AU - Gunn, G. Brandon

AU - Fuller, C. David

AU - Hutcheson, Katherine

AU - Lai, Stephen

AU - Busse, Paul M.

AU - Lee, Nancy Y.

AU - Lin, Alexander

AU - Foote, Robert L.

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AB - Intensity-modulated proton therapy minimizes the incidental irradiation of normal tissues in patients with head and neck cancer relative to intensity-modulated photon (x-ray) therapy and has been associated with lesser treatment-related toxicity and improved quality of life. A phase II/III randomized trial sponsored by the US National Cancer Institute is currently underway to compare deintensification treatment strategies with intensity-modulated proton therapy vs intensity-modulated photon (x-ray) therapy for patients with advanced-stage oropharyngeal tumors. After significant input from numerous stakeholders, the phase III portion of the randomized trial was redesigned as a noninferiority trial with progression-free survival as the primary endpoint. The process by which that redesign took place is described here.

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Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation

Abstract

All Science Journal Classification (ASJC) codes

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