Comparison of disease profiles and three-month outcomes of patients with neurological disorders with and without COVID-19: An ambispective cohort study

Kanchana Pillai, Deepti Vibha, Pranjal Gupta, Pachipala Sudheer, Biswamohan Mishra, Rahul Oinam, Ayush Mohan, Kamalesh Tayade, Padma Srivastava, Manjari Tripathi, Achal Srivastava, Rohit Bhatia, Roopa Rajan, Awadh Pandit, Rajesh Singh, Arunmozhimaran Elavarasi, Ayush Agarwal, Anu Gupta, Animesh Das, Divya RadhakrishnanBhargavi Ramanujam, Kapil Soni, Richa Aggarwal, Naveet Wig, Anjan Trikha

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: Neurological emergencies saw a paradigm shift in approach during the coronavirus disease-2019 (COVID-19) pandemic with the challenge to manage patients with and without COVID-19. We aimed to compare the various neurological disorders and 3 months outcome in patients with and without SARS-CoV-2 infection. Methods: In an ambispective cohort study design, we enrolled patients with and without SARS CoV-2 infection coming to a medical emergency with neurological disorders between April 2020 and September 2020. Demographic, clinical, biochemical, and treatment details of these patients were collected and compared. Their outcomes, both in-hospital and at 3 months were assessed by the modified Rankin Scale (mRS). Results: Two thirty-five patients (235) were enrolled from emergency services with neurological disorders. Of them, 81 (34.5%) were COVID-19 positive. The mean (SD) age was 49.5 (17.3) years, and the majority of the patients were male (63.0%). The commonest neurological diagnosis was acute ischemic stroke (AIS) (43.0%). The in-hospital mortality was higher in the patients who were COVID-19 positive (COVID-19 positive: 29 (35.8%) versus COVID-19 negative: 12 (7.8%), P value: <0.001). The 3 months telephonic follow-up could be completed in 73.2% of the patients (142/194). Four (12.1%) deaths occurred on follow-up in the COVID-19 positive versus fifteen (13.8%) in the COVID-19 negative patients (P value: 1.00). The 3-month mRS was worse in the COVID-19 positive group (P value <0.001). However, this was driven by higher in-hospital morbidity and mortality in COVID-19 positive patients. Conclusion: Patients with neurological disorders presenting with COVID-19 infection had worse outcomes, including in-hospital and 3 months disability.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalAnnals of Indian Academy of Neurology
Volume25
Issue number2
DOIs
StatePublished - Mar 1 2022

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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