Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity

W. O. Cook; V. R. Beasley; A. M. Dahlem; J. A. Dellinger; K. S. Harlin; W. W. Carmichael

doi:10.1016/0041-0101(88)90282-6

Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity

W. O. Cook, V. R. Beasley, A. M. Dahlem, J. A. Dellinger, K. S. Harlin, W. W. Carmichael

Veterinary and Biomedical Sciences

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Abstract

Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26, 750 - 753, 1988. - Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood - brain barrier.

Original language	English (US)
Pages (from-to)	750-753
Number of pages	4
Journal	Toxicon
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/0041-0101(88)90282-6
State	Published - 1988

All Science Journal Classification (ASJC) codes

Toxicology

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10.1016/0041-0101(88)90282-6

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title = "Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity",

abstract = "Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26, 750 - 753, 1988. - Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood - brain barrier.",

author = "Cook, {W. O.} and Beasley, {V. R.} and Dahlem, {A. M.} and Dellinger, {J. A.} and Harlin, {K. S.} and Carmichael, {W. W.}",

year = "1988",

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AU - Cook, W. O.

AU - Beasley, V. R.

AU - Dahlem, A. M.

AU - Dellinger, J. A.

AU - Harlin, K. S.

AU - Carmichael, W. W.

PY - 1988

Y1 - 1988

N2 - Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26, 750 - 753, 1988. - Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood - brain barrier.

AB - Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26, 750 - 753, 1988. - Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood - brain barrier.

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Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity

Abstract

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