Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity

W. O. Cook; V. R. Beasley; A. M. Dahlem; J. A. Dellinger; K. S. Harlin; W. W. Carmichael

doi:10.1016/0041-0101(88)90282-6

Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity

W. O. Cook
, V. R. Beasley
, A. M. Dahlem
, J. A. Dellinger
, K. S. Harlin
, W. W. Carmichael

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26, 750 - 753, 1988. - Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood - brain barrier.

Original language	English (US)
Pages (from-to)	750-753
Number of pages	4
Journal	Toxicon
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/0041-0101(88)90282-6
State	Published - 1988

All Science Journal Classification (ASJC) codes

Toxicology

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10.1016/0041-0101(88)90282-6

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title = "Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity",

abstract = "Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26, 750 - 753, 1988. - Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood - brain barrier.",

author = "Cook, \{W. O.\} and Beasley, \{V. R.\} and Dahlem, \{A. M.\} and Dellinger, \{J. A.\} and Harlin, \{K. S.\} and Carmichael, \{W. W.\}",

year = "1988",

doi = "10.1016/0041-0101(88)90282-6",

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T1 - Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity

AU - Cook, W. O.

AU - Beasley, V. R.

AU - Dahlem, A. M.

AU - Dellinger, J. A.

AU - Harlin, K. S.

AU - Carmichael, W. W.

PY - 1988

Y1 - 1988

N2 - Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26, 750 - 753, 1988. - Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood - brain barrier.

AB - Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26, 750 - 753, 1988. - Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood - brain barrier.

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DO - 10.1016/0041-0101(88)90282-6

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Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity

Abstract

All Science Journal Classification (ASJC) codes

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