Comparison of factor VIII levels after adrenalin in classic hemophilia and von Willebrand's disease (vWd)

M. E. Eyster; James Ballard; D. Prager

doi:10.1055/s-0038-1646740

Comparison of factor VIII levels after adrenalin in classic hemophilia and von Willebrand's disease (vWd)

M. E. Eyster, James Ballard, D. Prager

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Abstract

The factor VIII response to adrenalin was compared in 5 patients with von Willebrand's disease (vWd) and 10 hemophiliacs with baseline factor VIII procoagulant activity (VIII AHF) of 0.01 u/ml or greater. Patients with vWd showed a two-fold VIII AHF increase, while those with hemophilia showed no significant change 1 hr following the subcutaneous injection of adrenalin. These results suggest that the adrenalin stimulation test may be of value in distinguishing certain patients with mild hemophilia from those with vWd.

Original language	English (US)
Pages (from-to)	657-662
Number of pages	6
Journal	Thrombosis and Haemostasis
Volume	39
Issue number	3
DOIs	https://doi.org/10.1055/s-0038-1646740
State	Published - 1978

All Science Journal Classification (ASJC) codes

Hematology

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abstract = "The factor VIII response to adrenalin was compared in 5 patients with von Willebrand's disease (vWd) and 10 hemophiliacs with baseline factor VIII procoagulant activity (VIII AHF) of 0.01 u/ml or greater. Patients with vWd showed a two-fold VIII AHF increase, while those with hemophilia showed no significant change 1 hr following the subcutaneous injection of adrenalin. These results suggest that the adrenalin stimulation test may be of value in distinguishing certain patients with mild hemophilia from those with vWd.",

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N2 - The factor VIII response to adrenalin was compared in 5 patients with von Willebrand's disease (vWd) and 10 hemophiliacs with baseline factor VIII procoagulant activity (VIII AHF) of 0.01 u/ml or greater. Patients with vWd showed a two-fold VIII AHF increase, while those with hemophilia showed no significant change 1 hr following the subcutaneous injection of adrenalin. These results suggest that the adrenalin stimulation test may be of value in distinguishing certain patients with mild hemophilia from those with vWd.

AB - The factor VIII response to adrenalin was compared in 5 patients with von Willebrand's disease (vWd) and 10 hemophiliacs with baseline factor VIII procoagulant activity (VIII AHF) of 0.01 u/ml or greater. Patients with vWd showed a two-fold VIII AHF increase, while those with hemophilia showed no significant change 1 hr following the subcutaneous injection of adrenalin. These results suggest that the adrenalin stimulation test may be of value in distinguishing certain patients with mild hemophilia from those with vWd.

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Comparison of factor VIII levels after adrenalin in classic hemophilia and von Willebrand's disease (vWd)

Abstract

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