Comparison of losartan and amlodipine effects on the outcomes of patient with COVID-19 and primary hypertension: A randomised clinical trial

Masoud Nouri-Vaskeh, Niusha Kalami, Ramin Zand, Zahra Soroureddin, Mojtaba Varshochi, Khalil Ansarin, Haleh Rezaee, Ali Taghizadieh, Armin Sadeghi, Masoud Ahangari Maleki, Azam Esmailnajad, Parviz Saleh, Mehdi Haghdoost, Mehdi Maleki, Akbar Sharifi

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Background: Controversy exists regarding the drug selection in hypertension (HTN) management in patients with COVID-19. This study aimed to compare the effects of losartan and amlodipine in patients with primary HTN and COVID-19. Methods: In this randomised clinical trial, hospitalised patients with COVID-19 and primary HTN were enrolled in the study. One arm received losartan, 25 mg, twice a day and the other arm received amlodipine, 5 mg per day for 2 weeks. The main outcomes were compare 30-day mortality rate and length of hospital stay. Results: The mean age of patients treated with losartan (N = 41) and amlodipine (N = 39) was 67.3 ± 14.8 and 60.1 ± 17.3 years, respectively (P value =.068). The length of hospital stay in losartan and amlodipine groups was 4.57 ± 2.59 and 7.30 ± 8.70 days, respectively (P value =.085). Also, the length of ICU admission in losartan and amlodipine group was 7.13 ± 5.99 and 7.15 ± 9.95 days, respectively (P value =.994). The 30-day mortality was two and five patients in losartan and amlodipine groups, respectively (P value =.241). Conclusions: There was no priority in losartan or amlodipine administration in COVID-19 patients with primary HTN in decreasing mortality rate, hospital and ICU length stay. Further studies need to clarify the first-line anti-HTN medications in COVID-19.

Original languageEnglish (US)
Article numbere14124
JournalInternational Journal of Clinical Practice
Volume75
Issue number6
DOIs
StatePublished - Jun 2021

All Science Journal Classification (ASJC) codes

  • General Medicine

Fingerprint

Dive into the research topics of 'Comparison of losartan and amlodipine effects on the outcomes of patient with COVID-19 and primary hypertension: A randomised clinical trial'. Together they form a unique fingerprint.

Cite this