Comparison of risperidone and olanzapine in bipolar and schizoaffective disorders

Prakash S. Masand, Xiaohong Wang, Sanjay Gupta, Thomas L. Schwartz, Subhdeep Virk, Ahmad Hameed

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: To compare risperidone and olanzapine for efficacy, tolerability, need for concomitant mood stabilizers, and cost of treatment in bipolar and schizoaffective disorders. Method: We conducted a retrospective chart review of 36 consecutive outpatients with DSM-IV bipolar or schizoaffective disorder seen in 3 settings who received risperidone or olanzapine for at least 1 month between May and August 1997. Results: The mean ±SD doses were.3.7 ±3.5 mg/day of risperidone and 12.0 ±5.4 mg/day of olanzapine, Between-treatment differences in patient characteristics, psychiatric history, Clinical Global Impressions scale ratings, and duration of treatment were not significant. Similar proportions of patients in the 2 groups reported side effects, including extrapyramidal symptoms, akathisia. tardive dyskinesia, and precipitation of mania by the respective drug. Patients in the olanzapine group received a significantly higher dose of concomitant lithium than those receiving risperidone (mean daily lithium doses: risperidone group, 750 ±150 mg; olanzapine group, 1211 ±186 mg; p =.006). The total daily acquisition cost per patient was SI 1.84 for olanzapine versus $5.81 for risperidone. Conclusion: Olanzapine and risperidone were equally efficacious and safe in the treatment of patients with bipolar or schizoaffective disorder, but treatment costs and dose of concomitant lithium were lower in risperidone-treated patients.

Original languageEnglish (US)
Pages (from-to)70-73
Number of pages4
JournalPrimary Care Companion to the Journal of Clinical Psychiatry
Issue number2
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health


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