Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group

M. Haring Sweeney; M. A. Fingerhut; D. G. Patterson; L. B. Connally; L. A. Piacitelli; J. A. Morris; A. L. Greife; R. W. Hornung; D. A. Marlow; J. E. Dugle; W. E. Halperin; L. L. Needham

doi:10.1016/0045-6535(90)90211-B

Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group

M. Haring Sweeney, M. A. Fingerhut, D. G. Patterson, L. B. Connally, L. A. Piacitelli, J. A. Morris, A. L. Greife, R. W. Hornung, D. A. Marlow, J. E. Dugle, W. E. Halperin, L. L. Needham

Forensic Science Program

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31 Scopus citations

Abstract

Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposure (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p< .0001).

Original language	English (US)
Pages (from-to)	993-1000
Number of pages	8
Journal	Chemosphere
Volume	20
Issue number	7-9
DOIs	https://doi.org/10.1016/0045-6535(90)90211-B
State	Published - 1990

All Science Journal Classification (ASJC) codes

Environmental Engineering
Environmental Chemistry
General Chemistry
Pollution
Health, Toxicology and Mutagenesis

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10.1016/0045-6535(90)90211-B

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Sweeney, M. H., Fingerhut, M. A., Patterson, D. G., Connally, L. B., Piacitelli, L. A., Morris, J. A., Greife, A. L., Hornung, R. W., Marlow, D. A., Dugle, J. E., Halperin, W. E., & Needham, L. L. (1990). Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group. Chemosphere, 20(7-9), 993-1000. https://doi.org/10.1016/0045-6535(90)90211-B

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title = "Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group",

abstract = "Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposure (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p< .0001).",

author = "Sweeney, {M. Haring} and Fingerhut, {M. A.} and Patterson, {D. G.} and Connally, {L. B.} and Piacitelli, {L. A.} and Morris, {J. A.} and Greife, {A. L.} and Hornung, {R. W.} and Marlow, {D. A.} and Dugle, {J. E.} and Halperin, {W. E.} and Needham, {L. L.}",

year = "1990",

doi = "10.1016/0045-6535(90)90211-B",

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AU - Sweeney, M. Haring

AU - Fingerhut, M. A.

AU - Patterson, D. G.

AU - Connally, L. B.

AU - Piacitelli, L. A.

AU - Morris, J. A.

AU - Greife, A. L.

AU - Hornung, R. W.

AU - Marlow, D. A.

AU - Dugle, J. E.

AU - Halperin, W. E.

AU - Needham, L. L.

PY - 1990

Y1 - 1990

N2 - Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposure (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p< .0001).

AB - Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposure (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p< .0001).

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Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group

Abstract

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