TY - GEN
T1 - Comparison of the chemoprotection conferred by grapefruit and isolated bioactive compounds against colon cancer
AU - Turner, Nancy D.
AU - Vanamala, Jairam
AU - Leonardi, Tety
AU - Patil, Bhimanagouda S.
AU - Murphy, Mary E.
AU - Liu, Yingxue C.
AU - Wang, Naisyin
AU - Pike, Leonard M.
AU - Chapkin, Robert S.
AU - Lupton, Joanne R.
PY - 2006
Y1 - 2006
N2 - Grapefruit, and isolated bioactive citrus compounds, are suggested to protect against some cancers. The ability of grapefruit pulp powder (irradiated or non-irradiated) and isolated compounds (apigenin, hesperidin, limonin, naringin, naringenin, nobiletin) to protect against colon cancer development were compared in Sprague Dawley rats. Rats were injected with saline or a colon carcinogen (azoxymethane, AOM, 15 mg/kg body weight, 2x, weeks 3 and 4) after starting the diets. All test diets, except hesperidin and nobiletin, reduced (P < 0.04) preneoplastic lesions (aberrant crypt foci, ACF) and increased (P < 0.05) apoptosis. Hesperidin, nobiletin and apigenin were the only diets that did not decrease (P < 0.04) proliferation of colonocytes. Untreated grapefruit pulp powder, limonin and naringenin prevented (P < 0.05) proliferative zone expansion in AOM-injected rats. The data indicate untreated grapefruit pulp powder, and certain isolated compounds, reduce ACF formation through changes in colonocyte proliferation and apoptosis. Because irradiated grapefruit pulp powder was not as effective as untreated grapefruit pulp powder in controlling proliferative zone expansion, it may not be as effective as untreated grapefruit pulp powder in colon cancer prevention.
AB - Grapefruit, and isolated bioactive citrus compounds, are suggested to protect against some cancers. The ability of grapefruit pulp powder (irradiated or non-irradiated) and isolated compounds (apigenin, hesperidin, limonin, naringin, naringenin, nobiletin) to protect against colon cancer development were compared in Sprague Dawley rats. Rats were injected with saline or a colon carcinogen (azoxymethane, AOM, 15 mg/kg body weight, 2x, weeks 3 and 4) after starting the diets. All test diets, except hesperidin and nobiletin, reduced (P < 0.04) preneoplastic lesions (aberrant crypt foci, ACF) and increased (P < 0.05) apoptosis. Hesperidin, nobiletin and apigenin were the only diets that did not decrease (P < 0.04) proliferation of colonocytes. Untreated grapefruit pulp powder, limonin and naringenin prevented (P < 0.05) proliferative zone expansion in AOM-injected rats. The data indicate untreated grapefruit pulp powder, and certain isolated compounds, reduce ACF formation through changes in colonocyte proliferation and apoptosis. Because irradiated grapefruit pulp powder was not as effective as untreated grapefruit pulp powder in controlling proliferative zone expansion, it may not be as effective as untreated grapefruit pulp powder in colon cancer prevention.
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U2 - 10.1021/bk-2006-0936.ch009
DO - 10.1021/bk-2006-0936.ch009
M3 - Conference contribution
AN - SCOPUS:36749080540
SN - 0841239576
SN - 9780841239579
T3 - ACS Symposium Series
SP - 121
EP - 129
BT - Potential Health Benefits of Citrus
PB - American Chemical Society
ER -