Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

Douglas R. Cavener

doi:10.1093/nar/15.4.1353

Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

Douglas R. Cavener

Research output: Contribution to journal › Article › peer-review

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Abstract

The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak (1) was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CANCAUG

Original language	English (US)
Pages (from-to)	1353-1361
Number of pages	9
Journal	Nucleic acids research
Volume	15
Issue number	4
DOIs	https://doi.org/10.1093/nar/15.4.1353
State	Published - Feb 25 1987

All Science Journal Classification (ASJC) codes

Genetics

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10.1093/nar/15.4.1353

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abstract = "The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak (1) was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CANCAUG",

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AB - The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak (1) was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CANCAUG

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Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

Abstract

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