TY - JOUR
T1 - Complement-regulatory proteins in severe malaria
T2 - Too little or too much of a good thing?
AU - Stoute, José A.
N1 - Funding Information:
This work was supported by the US Army Medical Research and Materiel Command, and a grant (RO1 HL 7502–03) from the National Heart, Lung and Blood Institute. I thank the many technicians, physicians and other medical personnel at the US Army Medical Research Unit and the Kenya Medical Research Institute (Kenya) who contributed to the observations that are the basis of the opinions expressed in this article. My views do not purport to reflect the position of the Department of the Army or the Department of Defense. The US Government has the right to retain a non-exclusive, royalty-free license in and to all copyright covering this article.
PY - 2005/5
Y1 - 2005/5
N2 - Data from several laboratories suggest that erythrocyte complement-regulatory proteins, in particular complement receptor 1 (CR1), are important in the pathogenesis of severe malaria. Additional studies suggest that the levels of expression of CR1 and the complement regulator CD55 on erythrocytes vary with age, being low in young children and increasing with age. It is proposed that the interplay between the rate at which immunity develops during malaria exposure and the changes in levels of erythrocyte complement-regulatory proteins that occur with age might contribute to the differences in epidemiology of severe malaria-associated anaemia and cerebral malaria.
AB - Data from several laboratories suggest that erythrocyte complement-regulatory proteins, in particular complement receptor 1 (CR1), are important in the pathogenesis of severe malaria. Additional studies suggest that the levels of expression of CR1 and the complement regulator CD55 on erythrocytes vary with age, being low in young children and increasing with age. It is proposed that the interplay between the rate at which immunity develops during malaria exposure and the changes in levels of erythrocyte complement-regulatory proteins that occur with age might contribute to the differences in epidemiology of severe malaria-associated anaemia and cerebral malaria.
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U2 - 10.1016/j.pt.2005.03.004
DO - 10.1016/j.pt.2005.03.004
M3 - Article
C2 - 15837610
AN - SCOPUS:17444432656
SN - 1471-4922
VL - 21
SP - 218
EP - 223
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 5
ER -
