Complement-regulatory proteins in severe malaria: Too little or too much of a good thing?

José A. Stoute

doi:10.1016/j.pt.2005.03.004

Complement-regulatory proteins in severe malaria: Too little or too much of a good thing?

José A. Stoute

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Data from several laboratories suggest that erythrocyte complement-regulatory proteins, in particular complement receptor 1 (CR1), are important in the pathogenesis of severe malaria. Additional studies suggest that the levels of expression of CR1 and the complement regulator CD55 on erythrocytes vary with age, being low in young children and increasing with age. It is proposed that the interplay between the rate at which immunity develops during malaria exposure and the changes in levels of erythrocyte complement-regulatory proteins that occur with age might contribute to the differences in epidemiology of severe malaria-associated anaemia and cerebral malaria.

Original language	English (US)
Pages (from-to)	218-223
Number of pages	6
Journal	Trends in Parasitology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.pt.2005.03.004
State	Published - May 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Parasitology
Infectious Diseases

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10.1016/j.pt.2005.03.004

Cite this

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title = "Complement-regulatory proteins in severe malaria: Too little or too much of a good thing?",

abstract = "Data from several laboratories suggest that erythrocyte complement-regulatory proteins, in particular complement receptor 1 (CR1), are important in the pathogenesis of severe malaria. Additional studies suggest that the levels of expression of CR1 and the complement regulator CD55 on erythrocytes vary with age, being low in young children and increasing with age. It is proposed that the interplay between the rate at which immunity develops during malaria exposure and the changes in levels of erythrocyte complement-regulatory proteins that occur with age might contribute to the differences in epidemiology of severe malaria-associated anaemia and cerebral malaria.",

author = "Stoute, \{Jos{\'e} A.\}",

note = "Funding Information: This work was supported by the US Army Medical Research and Materiel Command, and a grant (RO1 HL 7502–03) from the National Heart, Lung and Blood Institute. I thank the many technicians, physicians and other medical personnel at the US Army Medical Research Unit and the Kenya Medical Research Institute (Kenya) who contributed to the observations that are the basis of the opinions expressed in this article. My views do not purport to reflect the position of the Department of the Army or the Department of Defense. The US Government has the right to retain a non-exclusive, royalty-free license in and to all copyright covering this article.",

year = "2005",

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doi = "10.1016/j.pt.2005.03.004",

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N1 - Funding Information: This work was supported by the US Army Medical Research and Materiel Command, and a grant (RO1 HL 7502–03) from the National Heart, Lung and Blood Institute. I thank the many technicians, physicians and other medical personnel at the US Army Medical Research Unit and the Kenya Medical Research Institute (Kenya) who contributed to the observations that are the basis of the opinions expressed in this article. My views do not purport to reflect the position of the Department of the Army or the Department of Defense. The US Government has the right to retain a non-exclusive, royalty-free license in and to all copyright covering this article.

PY - 2005/5

Y1 - 2005/5

N2 - Data from several laboratories suggest that erythrocyte complement-regulatory proteins, in particular complement receptor 1 (CR1), are important in the pathogenesis of severe malaria. Additional studies suggest that the levels of expression of CR1 and the complement regulator CD55 on erythrocytes vary with age, being low in young children and increasing with age. It is proposed that the interplay between the rate at which immunity develops during malaria exposure and the changes in levels of erythrocyte complement-regulatory proteins that occur with age might contribute to the differences in epidemiology of severe malaria-associated anaemia and cerebral malaria.

AB - Data from several laboratories suggest that erythrocyte complement-regulatory proteins, in particular complement receptor 1 (CR1), are important in the pathogenesis of severe malaria. Additional studies suggest that the levels of expression of CR1 and the complement regulator CD55 on erythrocytes vary with age, being low in young children and increasing with age. It is proposed that the interplay between the rate at which immunity develops during malaria exposure and the changes in levels of erythrocyte complement-regulatory proteins that occur with age might contribute to the differences in epidemiology of severe malaria-associated anaemia and cerebral malaria.

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DO - 10.1016/j.pt.2005.03.004

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JF - Trends in Parasitology

IS - 5

ER -

Complement-regulatory proteins in severe malaria: Too little or too much of a good thing?

Abstract

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