Complementation of class II A alleles in the immune response to (GluLysTyr) polymers

C. H. Lai; U. M. Babu; K. Matsunaga; Z. A. Nagy; J. Klein; H. A. Turchin; P. H. Maurer

Complementation of class II A alleles in the immune response to (GluLysTyr) polymers

C. H. Lai, U. M. Babu, K. Matsunaga, Z. A. Nagy, J. Klein, H. A. Turchin, P. H. Maurer

Biology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the EαEβ class II MHC molecule (E) in most responder strains. Some nonresponder strains that carry responder Eβ, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing Eα chain needed for the expression of E molecules and responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2(f) and H-2(s), which result in E-nonexpressor F₁ hybrids, which are responders to GLT. The restriction element involved in this response is an A(f)/A(s) hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of α and β chains in heterozygotes can increase the immune potential of the individual.

Original language	English (US)
Pages (from-to)	38-48
Number of pages	11
Journal	Experimental and Clinical Immunogenetics
Volume	3
Issue number	1
State	Published - 1986

All Science Journal Classification (ASJC) codes

Immunology
Genetics
Genetics(clinical)

Cite this

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title = "Complementation of class II A alleles in the immune response to (GluLysTyr) polymers",

abstract = "The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the EαEβ class II MHC molecule (E) in most responder strains. Some nonresponder strains that carry responder Eβ, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing Eα chain needed for the expression of E molecules and responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2(f) and H-2(s), which result in E-nonexpressor F1 hybrids, which are responders to GLT. The restriction element involved in this response is an A(f)/A(s) hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of α and β chains in heterozygotes can increase the immune potential of the individual.",

author = "Lai, {C. H.} and Babu, {U. M.} and K. Matsunaga and Nagy, {Z. A.} and J. Klein and Turchin, {H. A.} and Maurer, {P. H.}",

year = "1986",

language = "English (US)",

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T1 - Complementation of class II A alleles in the immune response to (GluLysTyr) polymers

AU - Lai, C. H.

AU - Babu, U. M.

AU - Matsunaga, K.

AU - Nagy, Z. A.

AU - Klein, J.

AU - Turchin, H. A.

AU - Maurer, P. H.

PY - 1986

Y1 - 1986

N2 - The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the EαEβ class II MHC molecule (E) in most responder strains. Some nonresponder strains that carry responder Eβ, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing Eα chain needed for the expression of E molecules and responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2(f) and H-2(s), which result in E-nonexpressor F1 hybrids, which are responders to GLT. The restriction element involved in this response is an A(f)/A(s) hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of α and β chains in heterozygotes can increase the immune potential of the individual.

AB - The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the EαEβ class II MHC molecule (E) in most responder strains. Some nonresponder strains that carry responder Eβ, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing Eα chain needed for the expression of E molecules and responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2(f) and H-2(s), which result in E-nonexpressor F1 hybrids, which are responders to GLT. The restriction element involved in this response is an A(f)/A(s) hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of α and β chains in heterozygotes can increase the immune potential of the individual.

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Complementation of class II A alleles in the immune response to (GluLysTyr) polymers

Abstract

All Science Journal Classification (ASJC) codes

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