Complementation of class II A alleles in the immune response to (GluLysTyr) polymers

C. H. Lai, U. M. Babu, K. Matsunaga, Z. A. Nagy, J. Klein, H. A. Turchin, P. H. Maurer

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the EαEβ class II MHC molecule (E) in most responder strains. Some nonresponder strains that carry responder Eβ, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing Eα chain needed for the expression of E molecules and responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2(f) and H-2(s), which result in E-nonexpressor F1 hybrids, which are responders to GLT. The restriction element involved in this response is an A(f)/A(s) hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of α and β chains in heterozygotes can increase the immune potential of the individual.

Original languageEnglish (US)
Pages (from-to)38-48
Number of pages11
JournalExperimental and Clinical Immunogenetics
Issue number1
StatePublished - 1986

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)


Dive into the research topics of 'Complementation of class II A alleles in the immune response to (GluLysTyr) polymers'. Together they form a unique fingerprint.

Cite this