Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum

Mitchell S. Abrahamsen; Thomas J. Templeton; Shinichiro Enomoto; Juan E. Abrahante; Guan Zhu; Cheryl A. Lancto; Mingqi Deng; Chang Liu; Giovanni Widmer; Saul Tzipori; Gregory A. Buck; Ping Xu; Alan T. Bankier; Paul H. Dear; Bernard A. Konfortov; Helen F. Spriggs; Lakshminarayan Iyer; Vivek Anantharaman; L. Aravind; Vivek Kapur

doi:10.1126/science.1094786

Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum

Mitchell S. Abrahamsen, Thomas J. Templeton, Shinichiro Enomoto, Juan E. Abrahante, Guan Zhu, Cheryl A. Lancto, Mingqi Deng, Chang Liu, Giovanni Widmer, Saul Tzipori, Gregory A. Buck, Ping Xu, Alan T. Bankier, Paul H. Dear, Bernard A. Konfortov, Helen F. Spriggs, Lakshminarayan Iyer, Vivek Anantharaman, L. Aravind, Vivek Kapur

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805 Scopus citations

Abstract

The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma, the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development.

Original language	English (US)
Pages (from-to)	441-445
Number of pages	5
Journal	Science
Volume	304
Issue number	5669
DOIs	https://doi.org/10.1126/science.1094786
State	Published - Apr 16 2004

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Abrahamsen, M. S., Templeton, T. J., Enomoto, S., Abrahante, J. E., Zhu, G., Lancto, C. A., Deng, M., Liu, C., Widmer, G., Tzipori, S., Buck, G. A., Xu, P., Bankier, A. T., Dear, P. H., Konfortov, B. A., Spriggs, H. F., Iyer, L., Anantharaman, V., Aravind, L., & Kapur, V. (2004). Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum. Science, 304(5669), 441-445. https://doi.org/10.1126/science.1094786

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title = "Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum",

abstract = "The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma, the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development.",

author = "Abrahamsen, {Mitchell S.} and Templeton, {Thomas J.} and Shinichiro Enomoto and Abrahante, {Juan E.} and Guan Zhu and Lancto, {Cheryl A.} and Mingqi Deng and Chang Liu and Giovanni Widmer and Saul Tzipori and Buck, {Gregory A.} and Ping Xu and Bankier, {Alan T.} and Dear, {Paul H.} and Konfortov, {Bernard A.} and Spriggs, {Helen F.} and Lakshminarayan Iyer and Vivek Anantharaman and L. Aravind and Vivek Kapur",

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doi = "10.1126/science.1094786",

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Abrahamsen, MS, Templeton, TJ, Enomoto, S, Abrahante, JE, Zhu, G, Lancto, CA, Deng, M, Liu, C, Widmer, G, Tzipori, S, Buck, GA, Xu, P, Bankier, AT, Dear, PH, Konfortov, BA, Spriggs, HF, Iyer, L, Anantharaman, V, Aravind, L & Kapur, V 2004, 'Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum', Science, vol. 304, no. 5669, pp. 441-445. https://doi.org/10.1126/science.1094786

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AU - Abrahamsen, Mitchell S.

AU - Templeton, Thomas J.

AU - Enomoto, Shinichiro

AU - Abrahante, Juan E.

AU - Zhu, Guan

AU - Lancto, Cheryl A.

AU - Deng, Mingqi

AU - Liu, Chang

AU - Widmer, Giovanni

AU - Tzipori, Saul

AU - Buck, Gregory A.

AU - Xu, Ping

AU - Bankier, Alan T.

AU - Dear, Paul H.

AU - Konfortov, Bernard A.

AU - Spriggs, Helen F.

AU - Iyer, Lakshminarayan

AU - Anantharaman, Vivek

AU - Aravind, L.

AU - Kapur, Vivek

PY - 2004/4/16

Y1 - 2004/4/16

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AB - The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma, the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development.

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JO - Science

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Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum

Abstract

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