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Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer

  • Ellen Finnegan
  • , Wei Ding
  • , Ziga Ude
  • , Sara Terer
  • , Tadhg McGivern
  • , Anna M. Blümel
  • , Grainne Kirwan
  • , Xinxin Shao
  • , Flavia Genua
  • , Xiaofei Yin
  • , Alexander Kel
  • , Sarinj Fattah
  • , Parvathi A. Myer
  • , Sally Ann Cryan
  • , Jochen H.M. Prehn
  • , Darran P. O’Connor
  • , Lorraine Brennan
  • , Gregory Yochum
  • , Celine J. Marmion
  • , Sudipto Das

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Pharmacology, Toxicology and Pharmaceutical Science