Complications from stereotactic body radiotherapy for lung cancer

Kylie H. Kang, Christian C. Okoye, Ravi B. Patel, Shankar Siva, Tithi Biswas, Rodney J. Ellis, Min Yao, Mitchell Machtay, Simon S. Lo

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


Stereotactic body radiotherapy (SBRT) has become a standard treatment option for early stage, node negative non-small cell lung cancer (NSCLC) in patients who are either medically inoperable or refuse surgical resection. SBRT has high local control rates and a favorable toxicity profile relative to other surgical and non-surgical approaches. Given the excellent tumor control rates and increasing utilization of SBRT, recent efforts have focused on limiting toxicity while expanding treatment to increasingly complex patients. We review toxicities from SBRT for lung cancer, including central airway, esophageal, vascular (e.g., aorta), lung parenchyma (e.g., radiation pneumonitis), and chest wall toxicities, as well as radiation-induced neuropathies (e.g., brachial plexus, vagus nerve and recurrent laryngeal nerve). We summarize patient-related, tumor-related, dosimetric characteristics of these toxicities, review published dose constraints, and propose strategies to reduce such complications.

Original languageEnglish (US)
Pages (from-to)981-1004
Number of pages24
Issue number2
StatePublished - 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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