TY - JOUR
T1 - Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase
AU - Uchimaru, Tadafumi
AU - Tsuzuki, Seiji
AU - Tanabe, Kazutoshi
AU - Benkovic, Stephen J.
AU - Furukawa, Kensuke
AU - Taira, Kazunari
PY - 1989/5/30
Y1 - 1989/5/30
N2 - The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7,8-dihydropterin as the model compound for the natural substrate, dihydrofolate.
AB - The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7,8-dihydropterin as the model compound for the natural substrate, dihydrofolate.
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U2 - 10.1016/0006-291X(89)91560-X
DO - 10.1016/0006-291X(89)91560-X
M3 - Article
C2 - 2730668
AN - SCOPUS:0024396406
SN - 0006-291X
VL - 161
SP - 64
EP - 68
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -