Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase

Tadafumi Uchimaru; Seiji Tsuzuki; Kazutoshi Tanabe; Stephen J. Benkovic; Kensuke Furukawa; Kazunari Taira

doi:10.1016/0006-291X(89)91560-X

Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase

Tadafumi Uchimaru
, Seiji Tsuzuki
, Kazutoshi Tanabe
, Stephen J. Benkovic
, Kensuke Furukawa
, Kazunari Taira

Chemistry

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7,8-dihydropterin as the model compound for the natural substrate, dihydrofolate.

Original language	English (US)
Pages (from-to)	64-68
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	161
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(89)91560-X
State	Published - May 30 1989

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(89)91560-X

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abstract = "The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7,8-dihydropterin as the model compound for the natural substrate, dihydrofolate.",

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AU - Uchimaru, Tadafumi

AU - Tsuzuki, Seiji

AU - Tanabe, Kazutoshi

AU - Benkovic, Stephen J.

AU - Furukawa, Kensuke

AU - Taira, Kazunari

PY - 1989/5/30

Y1 - 1989/5/30

N2 - The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7,8-dihydropterin as the model compound for the natural substrate, dihydrofolate.

AB - The significance of the enol form of the pterin ring in enzymatic reduction of dihydrofolate by DHFR is discussed on the basis of the results of ab initio calculations carried out on the keto/enol tautomers of 6-methyl-7,8-dihydropterin as the model compound for the natural substrate, dihydrofolate.

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Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase

Abstract

All Science Journal Classification (ASJC) codes

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