Computational view of surface based organic mass spectrometry

Barbara J. Garrison, Zbigniew Postawa

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Surface based mass spectrometric approaches fill an important niche in the mass analysis portfolio of tools. The particular niche depends on both the underlying physics and chemistry of molecule ejection as well as experimental characteristics. In this article, we use molecular dynamics computer simulations to elucidate the fundamental processes giving rise to ejection of organic molecules in atomic and cluster secondary ion mass spectrometry (SIMS), massive cluster impact (MCI) mass spectrometry, and matrix-assisted laser desorption ionization (MALDI) mass spectrometry. This review is aimed at graduate students and experimental researchers.

Original languageEnglish (US)
Pages (from-to)289-315
Number of pages27
JournalMass Spectrometry Reviews
Issue number4
StatePublished - Jul 2008

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Condensed Matter Physics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Spectroscopy


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