TY - JOUR
T1 - Concise Review
T2 - Bioprinting of Stem Cells for Transplantable Tissue Fabrication
AU - Leberfinger, Ashley N.
AU - Ravnic, Dino J.
AU - Dhawan, Aman
AU - Ozbolat, Ibrahim T.
N1 - Funding Information:
This work was supported by the U.S. National Science Foundation CMMI Awards 1349716 (ITO) and 1462232 (ITO), Diabetes in Action Research and Education Foundation Grant 426 (ITO), the Osteology Foundation Grant 15-042 (ITO), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under BIRCWH award K12HD055882 “Career Development Program in Women’s Health Research at Penn State” (DJR). The content is solely the responsibility of the authors and does not necessarily represent the official views of the abovementioned funding agencies.
Publisher Copyright:
© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press
PY - 2017/10
Y1 - 2017/10
N2 - Bioprinting is a quickly progressing technology, which holds the potential to generate replacement tissues and organs. Stem cells offer several advantages over differentiated cells for use as starting materials, including the potential for autologous tissue and differentiation into multiple cell lines. The three most commonly used stem cells are embryonic, induced pluripotent, and adult stem cells. Cells are combined with various natural and synthetic materials to form bioinks, which are used to fabricate scaffold-based or scaffold-free constructs. Computer aided design technology is combined with various bioprinting modalities including droplet-, extrusion-, or laser-based bioprinting to create tissue constructs. Each bioink and modality has its own advantages and disadvantages. Various materials and techniques are combined to maximize the benefits. Researchers have been successful in bioprinting cartilage, bone, cardiac, nervous, liver, and vascular tissues. However, a major limitation to clinical translation is building large-scale vascularized constructs. Many challenges must be overcome before this technology is used routinely in a clinical setting. Stem Cells Translational Medicine 2017;6:1940–1948.
AB - Bioprinting is a quickly progressing technology, which holds the potential to generate replacement tissues and organs. Stem cells offer several advantages over differentiated cells for use as starting materials, including the potential for autologous tissue and differentiation into multiple cell lines. The three most commonly used stem cells are embryonic, induced pluripotent, and adult stem cells. Cells are combined with various natural and synthetic materials to form bioinks, which are used to fabricate scaffold-based or scaffold-free constructs. Computer aided design technology is combined with various bioprinting modalities including droplet-, extrusion-, or laser-based bioprinting to create tissue constructs. Each bioink and modality has its own advantages and disadvantages. Various materials and techniques are combined to maximize the benefits. Researchers have been successful in bioprinting cartilage, bone, cardiac, nervous, liver, and vascular tissues. However, a major limitation to clinical translation is building large-scale vascularized constructs. Many challenges must be overcome before this technology is used routinely in a clinical setting. Stem Cells Translational Medicine 2017;6:1940–1948.
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U2 - 10.1002/sctm.17-0148
DO - 10.1002/sctm.17-0148
M3 - Review article
C2 - 28836738
AN - SCOPUS:85030239410
SN - 2157-6564
VL - 6
SP - 1940
EP - 1948
JO - Stem Cells Translational Medicine
JF - Stem Cells Translational Medicine
IS - 10
ER -