TY - JOUR
T1 - Concise Synthesis of a Potential 5-Lipoxygenase Activating Protein (FLAP) Inhibitor and Its Analogs through Late-Stage Alkene Dicarbofunctionalization
AU - Kc, Shekhar
AU - Dhungana, Roshan K.
AU - Aryal, Vivek
AU - Giri, Ramesh
PY - 2019/8/16
Y1 - 2019/8/16
N2 - We report a five-step synthesis of the biologically important 1,1-diarylalkane 1, a potential 5-lipoxygenase activating protein (FLAP) inhibitor that was synthesized previously in 12 steps. In this synthesis, we apply a three-component alkene dicarbofunctionalization reaction as a key final step to assemble the potential FLAP inhibitor 1 from commercially available starting materials. In addition, we also report the synthesis of a variety of new analogs of the inhibitor 1 and its regioisomer.
AB - We report a five-step synthesis of the biologically important 1,1-diarylalkane 1, a potential 5-lipoxygenase activating protein (FLAP) inhibitor that was synthesized previously in 12 steps. In this synthesis, we apply a three-component alkene dicarbofunctionalization reaction as a key final step to assemble the potential FLAP inhibitor 1 from commercially available starting materials. In addition, we also report the synthesis of a variety of new analogs of the inhibitor 1 and its regioisomer.
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U2 - 10.1021/acs.oprd.9b00199
DO - 10.1021/acs.oprd.9b00199
M3 - Article
AN - SCOPUS:85068113117
SN - 1083-6160
VL - 23
SP - 1686
EP - 1694
JO - Organic Process Research and Development
JF - Organic Process Research and Development
IS - 8
ER -