TY - GEN
T1 - Conducting polymer microcontainers for biomedical applications
AU - Khorrami, Milad
AU - Antensteiner, Martin
AU - Fallahianbijan, Fatemeh
AU - Borhan, Ali
AU - Abidian, Mohammad Reza
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/9/13
Y1 - 2017/9/13
N2 - Advancement in the development of metallic-based implantable micro-scale bioelectronics has been limited by low signal to noise ratios and low charge injection at electrode-tissue interfaces. Further, implantable electrodes lose their long-term functionality because of unfavorable reactive tissue responses. Thus, substantial incentive exists to produce bioelectronics capable of delivering therapeutic compounds while improving electrical performance. Here, we have produced hollow poly(pyrrole) microcontainers (MCs) using poly(lactic-co-glycolic) acid (PLGA) as degradable templates. We demonstrate that the effective surface area of the electrode increases significantly as deposition charge density is increased, resulting in a 91% decrease in impedance and an 85% increase in charge storage capacity versus uncoated gold electrodes. We also developed an equivalent circuit model to quantify the effect of conducting polymer film growth on impedance. These MC-modified electrodes offer the potential to improve the electrical properties of implantable bioelectronics, as well as provide potential controlled release avenues for drug delivery applications.
AB - Advancement in the development of metallic-based implantable micro-scale bioelectronics has been limited by low signal to noise ratios and low charge injection at electrode-tissue interfaces. Further, implantable electrodes lose their long-term functionality because of unfavorable reactive tissue responses. Thus, substantial incentive exists to produce bioelectronics capable of delivering therapeutic compounds while improving electrical performance. Here, we have produced hollow poly(pyrrole) microcontainers (MCs) using poly(lactic-co-glycolic) acid (PLGA) as degradable templates. We demonstrate that the effective surface area of the electrode increases significantly as deposition charge density is increased, resulting in a 91% decrease in impedance and an 85% increase in charge storage capacity versus uncoated gold electrodes. We also developed an equivalent circuit model to quantify the effect of conducting polymer film growth on impedance. These MC-modified electrodes offer the potential to improve the electrical properties of implantable bioelectronics, as well as provide potential controlled release avenues for drug delivery applications.
UR - http://www.scopus.com/inward/record.url?scp=85032209520&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032209520&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2017.8037211
DO - 10.1109/EMBC.2017.8037211
M3 - Conference contribution
C2 - 29060255
AN - SCOPUS:85032209520
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1869
EP - 1872
BT - 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Y2 - 11 July 2017 through 15 July 2017
ER -