Confidence interval about the response at the stationary point of a response surface, with an application to preclinical cancer therapy.

W. H. Carter; V. M. Chinchilli; E. D. Campbell; G. L. Wampler

doi:10.2307/2531164

Confidence interval about the response at the stationary point of a response surface, with an application to preclinical cancer therapy.

W. H. Carter, V. M. Chinchilli, E. D. Campbell, G. L. Wampler

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18 Scopus citations

Abstract

A method of calculating a confidence interval about the response at the stationary point of a response surface is presented. We show that the technique can also be used to calculate a confidence region about the location of the stationary point. The procedure is applied, via Cox's proportional-hazards model, to the analysis of survival data from a preclinical cancer chemotherapy experiment involving the combination of two drugs. It is seen that the results can be useful in determining the existence of a therapeutic synergism.

Original language	English (US)
Pages (from-to)	1125-1130
Number of pages	6
Journal	Biometrics
Volume	40
Issue number	4
DOIs	https://doi.org/10.2307/2531164
State	Published - Dec 1984

All Science Journal Classification (ASJC) codes

Statistics and Probability
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

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10.2307/2531164

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Confidence interval about the response at the stationary point of a response surface, with an application to preclinical cancer therapy.

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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