TY - JOUR
T1 - Confirmation of whole-brain kindling with repeated subthreshold electroconvulsive shocks
T2 - A controlled study
AU - Andrade, Chittaranjan
AU - Akki, Ashwin
AU - Nandakumar, Nagaraja
AU - Chandra, J. Suresh
PY - 2003
Y1 - 2003
N2 - Background: Repeated, subconvulsive electroconvulsive shock (ECS) stimuli, administered a day apart, lower the ECS seizure threshold in rats. It is not known, however, whether this kindling results from the repeated subconvulsive stimulation or from the stress induced by the experimental procedures. Materials and Methods: Adult, male Wistar rats were randomized to receive a 3-mC ECS stimulus (n = 20), a 30-V (0.3-s) footpad shock (n = 20), or sham ECS and sham footpad shock (n = 20). All procedures were conducted once daily for 3 consecutive days. On the fourth day, all rats received a 3-mC ECS stimulus. Results: At the end of the experiment, 85% of the rats in the ECS group but only 35% of the rats in each of the other two groups had experienced a seizure with the 3-mC stimulus (p < 0.001). Conclusion: The lowering of the ECS seizure threshold by repeated, once-daily subconvulsive stimuli is caused by the subconvulsive stimulation itself, not by experimental stress.
AB - Background: Repeated, subconvulsive electroconvulsive shock (ECS) stimuli, administered a day apart, lower the ECS seizure threshold in rats. It is not known, however, whether this kindling results from the repeated subconvulsive stimulation or from the stress induced by the experimental procedures. Materials and Methods: Adult, male Wistar rats were randomized to receive a 3-mC ECS stimulus (n = 20), a 30-V (0.3-s) footpad shock (n = 20), or sham ECS and sham footpad shock (n = 20). All procedures were conducted once daily for 3 consecutive days. On the fourth day, all rats received a 3-mC ECS stimulus. Results: At the end of the experiment, 85% of the rats in the ECS group but only 35% of the rats in each of the other two groups had experienced a seizure with the 3-mC stimulus (p < 0.001). Conclusion: The lowering of the ECS seizure threshold by repeated, once-daily subconvulsive stimuli is caused by the subconvulsive stimulation itself, not by experimental stress.
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U2 - 10.1097/00124509-200306000-00004
DO - 10.1097/00124509-200306000-00004
M3 - Article
C2 - 12792455
AN - SCOPUS:0038621309
SN - 1095-0680
VL - 19
SP - 81
EP - 83
JO - Journal of ECT
JF - Journal of ECT
IS - 2
ER -
