Conformations of immunoglobulin hypervariable regions

Cyrus Chothia; Arthur M. Lesk; Anna Tramontano; Michael Levitt; Sandra J. Smith-Gill; Gillian Air; Steven Sheriff; Eduardo A. Padlan; David Davies; William R. Tulip; Peter M. Colman; Silvia Spinelli; Pedro M. Alzari; Roberto J. Poljak

doi:10.1038/342877a0

Conformations of immunoglobulin hypervariable regions

Cyrus Chothia, Arthur M. Lesk, Anna Tramontano, Michael Levitt, Sandra J. Smith-Gill, Gillian Air, Steven Sheriff, Eduardo A. Padlan, David Davies, William R. Tulip, Peter M. Colman, Silvia Spinelli, Pedro M. Alzari, Roberto J. Poljak

Biochemistry & Molecular Biology

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Abstract

On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues. These hypotheses are now supported by reasonably successful predictions of the structures of most hypervariable regions of various antibodies, as revealed by comparison with their subsequently determined structures.

Original language	English (US)
Pages (from-to)	877-883
Number of pages	7
Journal	Nature
Volume	342
Issue number	6252
DOIs	https://doi.org/10.1038/342877a0
State	Published - 1989

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title = "Conformations of immunoglobulin hypervariable regions",

abstract = "On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues. These hypotheses are now supported by reasonably successful predictions of the structures of most hypervariable regions of various antibodies, as revealed by comparison with their subsequently determined structures.",

author = "Cyrus Chothia and Lesk, {Arthur M.} and Anna Tramontano and Michael Levitt and Smith-Gill, {Sandra J.} and Gillian Air and Steven Sheriff and Padlan, {Eduardo A.} and David Davies and Tulip, {William R.} and Colman, {Peter M.} and Silvia Spinelli and Alzari, {Pedro M.} and Poljak, {Roberto J.}",

year = "1989",

doi = "10.1038/342877a0",

language = "English (US)",

volume = "342",

pages = "877--883",

journal = "Nature",

issn = "0028-0836",

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TY - JOUR

T1 - Conformations of immunoglobulin hypervariable regions

AU - Chothia, Cyrus

AU - Lesk, Arthur M.

AU - Tramontano, Anna

AU - Levitt, Michael

AU - Smith-Gill, Sandra J.

AU - Air, Gillian

AU - Sheriff, Steven

AU - Padlan, Eduardo A.

AU - Davies, David

AU - Tulip, William R.

AU - Colman, Peter M.

AU - Spinelli, Silvia

AU - Alzari, Pedro M.

AU - Poljak, Roberto J.

PY - 1989

Y1 - 1989

N2 - On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues. These hypotheses are now supported by reasonably successful predictions of the structures of most hypervariable regions of various antibodies, as revealed by comparison with their subsequently determined structures.

AB - On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues. These hypotheses are now supported by reasonably successful predictions of the structures of most hypervariable regions of various antibodies, as revealed by comparison with their subsequently determined structures.

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U2 - 10.1038/342877a0

DO - 10.1038/342877a0

M3 - Article

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SN - 0028-0836

VL - 342

SP - 877

EP - 883

JO - Nature

JF - Nature

IS - 6252

ER -

Conformations of immunoglobulin hypervariable regions

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