Connecting the dots between cell populations, whole-brain activity, and behavior

Lauren N. Beloate, Nanyin Zhang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Simultaneously manipulating and monitoring both microscopic and macroscopic brain activity in vivo and identifying the linkage to behavior are powerful tools in neuroscience research. These capabilities have been realized with the recent technical advances of optogenetics and its combination with fMRI, here termed "opto-fMRI."Opto-fMRI allows for targeted brain region-, cell-type-, or projection-specific manipulation and targeted Ca2 + activity measurement to be linked with global brain signaling and behavior. We cover the history, technical advances, applications, and important considerations of opto-fMRI in anesthetized and awake rodents and the future directions of the combined techniques in neuroscience and neuroimaging.

Original languageEnglish (US)
Article number032208
JournalNeurophotonics
Volume9
Issue number3
DOIs
StatePublished - Jul 1 2022

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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