Conservation of ancestral haplotypes telomeric of HLA-A

G. K. Tay, S. K. Cattley, M. J. Chorney, P. N. Hollingsworth, M. P. Roth, R. L. Dawkins, C. S. Witt

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Genes that predispose to haemochromatosis are thought to be located within the several megabases telomeric of HLA-A. Further recombinant mapping has been used previously to map susceptibility genes for diseases such as insulin-dependent diabetes mellitus, myasthenia gravis and cystic fibrosis, and should be useful in relation to haemochromatosis. However, this method requires the recognition of ancestral haplotypes within the susceptibility region. Using a panel of six microsatellite markers from this region (MOG A, MOG B, MOG C, D6S464, D6S306 and D6S105), we show that ancestral haplotypes extend telomeric of HLA-A, at least as far as D6S105. Nine of 14 haplotypes carrying HLA-B7 and HLA-A3 shared the same microsatellite alleles between HLA-A and at least D6S105. Similarly, nine of 10 haplotypes sharing HLA-B8 and HLA-A1 shared the same microsatellite alleles, although a different set to those with HLA-B7 and HLA-A3. Haplotypes representing historical recombination events were also identified. These two findings demonstrate that recombinant mapping may be applicable to the mapping of disease genes in this region.

Original languageEnglish (US)
Pages (from-to)275-285
Number of pages11
JournalEuropean Journal of Immunogenetics
Issue number4
StatePublished - 1997

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics


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