Constructing Aligned Sequence Blocks

Webb Miller, Mark Boguski, Balaji Raghavachari, Zheng Zhang, Ross C. Hardison

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


This paper presents an efficient method for constructing aligned blocks (i.e., gap-free multiple alignments) from a set of pairwise alignments. The method is more sensitive than some earlier block-constructing methods for detecting conserved sequence regions. The technique is applied to analyze conserved regions in protein prenyltransferases and to detect regulatory elements in the 5′ flank of the β-globin gene.

Original languageEnglish (US)
Pages (from-to)51-64
Number of pages14
JournalJournal of Computational Biology
Issue number1
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Modeling and Simulation
  • Molecular Biology
  • Genetics
  • Computational Mathematics
  • Computational Theory and Mathematics


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