Constructing Aligned Sequence Blocks

Webb Miller; Mark Boguski; Balaji Raghavachari; Zheng Zhang; Ross C. Hardison

doi:10.1089/cmb.1994.1.51

Constructing Aligned Sequence Blocks

Webb Miller, Mark Boguski, Balaji Raghavachari, Zheng Zhang, Ross C. Hardison

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7 Scopus citations

Abstract

This paper presents an efficient method for constructing aligned blocks (i.e., gap-free multiple alignments) from a set of pairwise alignments. The method is more sensitive than some earlier block-constructing methods for detecting conserved sequence regions. The technique is applied to analyze conserved regions in protein prenyltransferases and to detect regulatory elements in the 5′ flank of the β-globin gene.

Original language	English (US)
Pages (from-to)	51-64
Number of pages	14
Journal	Journal of Computational Biology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1089/cmb.1994.1.51
State	Published - 1994

All Science Journal Classification (ASJC) codes

Modeling and Simulation
Molecular Biology
Genetics
Computational Mathematics
Computational Theory and Mathematics

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10.1089/cmb.1994.1.51

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title = "Constructing Aligned Sequence Blocks",

abstract = "This paper presents an efficient method for constructing aligned blocks (i.e., gap-free multiple alignments) from a set of pairwise alignments. The method is more sensitive than some earlier block-constructing methods for detecting conserved sequence regions. The technique is applied to analyze conserved regions in protein prenyltransferases and to detect regulatory elements in the 5′ flank of the β-globin gene.",

author = "Webb Miller and Mark Boguski and Balaji Raghavachari and Zheng Zhang and Hardison, {Ross C.}",

year = "1994",

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AU - Boguski, Mark

AU - Raghavachari, Balaji

AU - Zhang, Zheng

AU - Hardison, Ross C.

PY - 1994

Y1 - 1994

N2 - This paper presents an efficient method for constructing aligned blocks (i.e., gap-free multiple alignments) from a set of pairwise alignments. The method is more sensitive than some earlier block-constructing methods for detecting conserved sequence regions. The technique is applied to analyze conserved regions in protein prenyltransferases and to detect regulatory elements in the 5′ flank of the β-globin gene.

AB - This paper presents an efficient method for constructing aligned blocks (i.e., gap-free multiple alignments) from a set of pairwise alignments. The method is more sensitive than some earlier block-constructing methods for detecting conserved sequence regions. The technique is applied to analyze conserved regions in protein prenyltransferases and to detect regulatory elements in the 5′ flank of the β-globin gene.

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U2 - 10.1089/cmb.1994.1.51

DO - 10.1089/cmb.1994.1.51

M3 - Article

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AN - SCOPUS:0028401943

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SP - 51

EP - 64

JO - Journal of Computational Biology

JF - Journal of Computational Biology

IS - 1

ER -

Constructing Aligned Sequence Blocks

Abstract

All Science Journal Classification (ASJC) codes

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