Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Jian Zhang, Jinpeng Jia, Jimin P. Kim, Fei Yang, Xing Wang, Hong Shen, Sijia Xu, Jian Yang, Decheng Wu

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalBioactive Materials
Issue number1
StatePublished - Mar 2018

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Biomedical Engineering


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