Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Jian Zhang; Jinpeng Jia; Jimin P. Kim; Fei Yang; Xing Wang; Hong Shen; Sijia Xu; Jian Yang; Decheng Wu

doi:10.1016/j.bioactmat.2017.06.003

Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Jian Zhang
, Jinpeng Jia
, Jimin P. Kim
, Fei Yang
, Xing Wang
, Hong Shen
, Sijia Xu
, Jian Yang
, Decheng Wu

Materials Research Institute (MRI)

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.

Original language	English (US)
Pages (from-to)	87-96
Number of pages	10
Journal	Bioactive Materials
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.bioactmat.2017.06.003
State	Published - Mar 2018

All Science Journal Classification (ASJC) codes

Biotechnology
Biomaterials
Biomedical Engineering

Access to Document

10.1016/j.bioactmat.2017.06.003

Cite this

@article{f828719a03a0401db34ec48d71204254,

title = "Construction of versatile multilayered composite nanoparticles from a customized nanogel template",

abstract = "We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.",

author = "Jian Zhang and Jinpeng Jia and Kim, \{Jimin P.\} and Fei Yang and Xing Wang and Hong Shen and Sijia Xu and Jian Yang and Decheng Wu",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2018",

month = mar,

doi = "10.1016/j.bioactmat.2017.06.003",

language = "English (US)",

volume = "3",

pages = "87--96",

journal = "Bioactive Materials",

issn = "2452-199X",

publisher = "KeAi Communications Co",

number = "1",

}

TY - JOUR

T1 - Construction of versatile multilayered composite nanoparticles from a customized nanogel template

AU - Zhang, Jian

AU - Jia, Jinpeng

AU - Kim, Jimin P.

AU - Yang, Fei

AU - Wang, Xing

AU - Shen, Hong

AU - Xu, Sijia

AU - Yang, Jian

AU - Wu, Decheng

PY - 2018/3

Y1 - 2018/3

N2 - We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.

AB - We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.

UR - https://www.scopus.com/pages/publications/85036566411

UR - https://www.scopus.com/pages/publications/85036566411#tab=citedBy

U2 - 10.1016/j.bioactmat.2017.06.003

DO - 10.1016/j.bioactmat.2017.06.003

M3 - Article

C2 - 29744445

AN - SCOPUS:85036566411

SN - 2452-199X

VL - 3

SP - 87

EP - 96

JO - Bioactive Materials

JF - Bioactive Materials

IS - 1

ER -

Construction of versatile multilayered composite nanoparticles from a customized nanogel template

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this