Contemporary strategies for weight loss and cardiovascular disease risk factor modification

Alison M. Hill, Penny M. Kris-Etherton

Research output: Contribution to journalArticlepeer-review


Because of the overweight/obesity epidemic and attendant increase in risk of chronic disease worldwide, there is a pressing need to identify effective weight loss strategies. Current recommendations for weight loss advocate a reduced-calorie dietary pattern (lower in total fat) in conjunction with regular physical activity and behavior change. This combined approach is important for long-term adherence and weight maintenance. Several large-scale clinical trials implementing different reduced-calorie dietary patterns have shown that 4 to 10 kg of weight is typically lost. The different hypocaloric dietary patterns shown to be effective include reduced-fat diets (10%-30% of calories from fat), a Mediterranean-style diet, and diets that are reduced in energy density. The weight loss achieved is accompanied by beneficial changes in cardiovascular disease risk, including the lipid and lipoprotein profile and blood pressure. This article summarizes our current understanding of effective weight loss programs.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalCurrent Cardiovascular Risk Reports
Issue number2
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


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