Contribution of perfusion pressure to vascular resistance response during head-up tilt

Virginia A. Imadojemu, Mary E.J. Lott, Kevin Gleeson, Cynthia S. Hogeman, Chester A. Ray, Lawrence Sinoway

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


We measured brachial and femoral artery flow velocity in eight subjects and peroneal and median muscle sympathetic nerve activity (MSNA) in five subjects during tilt testing to 40°. Tilt caused similar increases in MSNA in the peroneal and median nerves. Tilt caused a fall in femoral artery flow velocity, whereas no changes in flow velocity were seen in the brachial artery. Moreover, with tilt, the increase in the vascular resistance employed (blood pressure/flow velocity) was greater and more sustained in the leg than in the arm. The ratio of the percent increase in vascular resistance in leg to arm was 2.5:1. We suggest that the greater vascular resistance effects in the leg were due to an interaction between sympathetic nerve activity and the myogenic response.

Original languageEnglish (US)
Pages (from-to)H371-H375
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number1 50-1
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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