Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins

Nushrat J. Hoque; Emily E. Weinert

doi:10.1016/j.mib.2023.102396

Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins

Nushrat J. Hoque, Emily E. Weinert

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Bacteria sense and respond to their environment, allowing them to maximize their survival and growth under changing conditions, such as oxygen levels. Direct oxygen-sensing proteins allow bacteria to rapidly sense concentration changes and adapt by regulating signaling pathways and/or cellular machinery. Recent work has identified roles for direct oxygen-sensing proteins in controlling second messenger levels and motility machinery, as well as effects on biofilm formation, virulence, and motility. In this review, we discuss recent progress in understanding O₂-dependent regulation of cyclic di-GMP signaling and motility and highlight the emerging importance in controlling bacterial physiology and behavior.

Original language	English (US)
Article number	102396
Journal	Current Opinion in Microbiology
Volume	76
DOIs	https://doi.org/10.1016/j.mib.2023.102396
State	Published - Dec 2023

All Science Journal Classification (ASJC) codes

Microbiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mib.2023.102396

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title = "Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins",

abstract = "Bacteria sense and respond to their environment, allowing them to maximize their survival and growth under changing conditions, such as oxygen levels. Direct oxygen-sensing proteins allow bacteria to rapidly sense concentration changes and adapt by regulating signaling pathways and/or cellular machinery. Recent work has identified roles for direct oxygen-sensing proteins in controlling second messenger levels and motility machinery, as well as effects on biofilm formation, virulence, and motility. In this review, we discuss recent progress in understanding O2-dependent regulation of cyclic di-GMP signaling and motility and highlight the emerging importance in controlling bacterial physiology and behavior.",

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AU - Hoque, Nushrat J.

AU - Weinert, Emily E.

PY - 2023/12

Y1 - 2023/12

N2 - Bacteria sense and respond to their environment, allowing them to maximize their survival and growth under changing conditions, such as oxygen levels. Direct oxygen-sensing proteins allow bacteria to rapidly sense concentration changes and adapt by regulating signaling pathways and/or cellular machinery. Recent work has identified roles for direct oxygen-sensing proteins in controlling second messenger levels and motility machinery, as well as effects on biofilm formation, virulence, and motility. In this review, we discuss recent progress in understanding O2-dependent regulation of cyclic di-GMP signaling and motility and highlight the emerging importance in controlling bacterial physiology and behavior.

AB - Bacteria sense and respond to their environment, allowing them to maximize their survival and growth under changing conditions, such as oxygen levels. Direct oxygen-sensing proteins allow bacteria to rapidly sense concentration changes and adapt by regulating signaling pathways and/or cellular machinery. Recent work has identified roles for direct oxygen-sensing proteins in controlling second messenger levels and motility machinery, as well as effects on biofilm formation, virulence, and motility. In this review, we discuss recent progress in understanding O2-dependent regulation of cyclic di-GMP signaling and motility and highlight the emerging importance in controlling bacterial physiology and behavior.

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JO - Current Opinion in Microbiology

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Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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