Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins

Nushrat J. Hoque, Emily E. Weinert

Research output: Contribution to journalReview articlepeer-review


Bacteria sense and respond to their environment, allowing them to maximize their survival and growth under changing conditions, such as oxygen levels. Direct oxygen-sensing proteins allow bacteria to rapidly sense concentration changes and adapt by regulating signaling pathways and/or cellular machinery. Recent work has identified roles for direct oxygen-sensing proteins in controlling second messenger levels and motility machinery, as well as effects on biofilm formation, virulence, and motility. In this review, we discuss recent progress in understanding O2-dependent regulation of cyclic di-GMP signaling and motility and highlight the emerging importance in controlling bacterial physiology and behavior.

Original languageEnglish (US)
Article number102396
JournalCurrent Opinion in Microbiology
StatePublished - Dec 2023

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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