TY - GEN
T1 - Control of human immunodeficiency virus (HIV) dynamics with parameter uncertainties
AU - Karagiannis, Dimitri
AU - Radisavljevic-Gajic, Verica
AU - Ashrafiuon, Hashem
N1 - Publisher Copyright:
Copyright © 2016 by ASME.
PY - 2016
Y1 - 2016
N2 - This work considers a 3-state nonlinear model with two inputs for the controlled dynamics of the human immunodeficiency virus (HIV). The three states represent the number of healthy and unhealthy T-cells as well as the number of free virus particles in a person's body. The two inputs represent two different types of anti-retroviral drugs that are available to treat a person infected with the virus. These inputs can be used to create a stable nominal point that is much healthier for the patient than the open-loop stable equilibrium point. The goal of this paper is to use the inputs, which are subject to constraints, to efficiently and accurately reach the desired nominal point despite parameter uncertainties. We have designed an integral sliding mode control law to achieve this goal, and simulations are presented to demonstrate the performance of the controller.
AB - This work considers a 3-state nonlinear model with two inputs for the controlled dynamics of the human immunodeficiency virus (HIV). The three states represent the number of healthy and unhealthy T-cells as well as the number of free virus particles in a person's body. The two inputs represent two different types of anti-retroviral drugs that are available to treat a person infected with the virus. These inputs can be used to create a stable nominal point that is much healthier for the patient than the open-loop stable equilibrium point. The goal of this paper is to use the inputs, which are subject to constraints, to efficiently and accurately reach the desired nominal point despite parameter uncertainties. We have designed an integral sliding mode control law to achieve this goal, and simulations are presented to demonstrate the performance of the controller.
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U2 - 10.1115/DSCC2016-9755
DO - 10.1115/DSCC2016-9755
M3 - Conference contribution
AN - SCOPUS:85015966272
T3 - ASME 2016 Dynamic Systems and Control Conference, DSCC 2016
BT - Advances in Control Design Methods, Nonlinear and Optimal Control, Robotics, and Wind Energy Systems; Aerospace Applications; Assistive and Rehabilitation Robotics; Assistive Robotics; Battery and Oil and Gas Systems; Bioengineering Applications; Biomedical and Neural Systems Modeling, Diagnostics and Healthcare; Control and Monitoring of Vibratory Systems; Diagnostics and Detection; Energy Harvesting; Estimation and Identification; Fuel Cells/Energy Storage; Intelligent Transportation
PB - American Society of Mechanical Engineers
T2 - ASME 2016 Dynamic Systems and Control Conference, DSCC 2016
Y2 - 12 October 2016 through 14 October 2016
ER -
