Control of protein adsorption onto core-shell tubular and vesicular structures of diphenylalanine/parylene

Gökhan Demirel; Niranjan Malvadkar; Melik C. Demirel

doi:10.1021/la903571y

Control of protein adsorption onto core-shell tubular and vesicular structures of diphenylalanine/parylene

Gökhan Demirel, Niranjan Malvadkar, Melik C. Demirel

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The self-assembly of peptides, specifically dipeptides, offers numerous advantages for biological applications. We describe an easy, versatile method of fabricating different types of zwitterionic Phe-Phe dipeptide structures (i.e., tubes and vesicles) through solvent-mediated assembly. The stability of the dipeptide structures is increased by thin polymer coatings of poly(chloro-P-xylylene), a PPX film. We also investigated protein adsorption onto PPX-coated peptide tubes and vesicles by varying the thickness of the polymer film.

Original language	English (US)
Pages (from-to)	1460-1463
Number of pages	4
Journal	Langmuir
Volume	26
Issue number	3
DOIs	https://doi.org/10.1021/la903571y
State	Published - Feb 2 2010

All Science Journal Classification (ASJC) codes

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la903571y

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AB - The self-assembly of peptides, specifically dipeptides, offers numerous advantages for biological applications. We describe an easy, versatile method of fabricating different types of zwitterionic Phe-Phe dipeptide structures (i.e., tubes and vesicles) through solvent-mediated assembly. The stability of the dipeptide structures is increased by thin polymer coatings of poly(chloro-P-xylylene), a PPX film. We also investigated protein adsorption onto PPX-coated peptide tubes and vesicles by varying the thickness of the polymer film.

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Control of protein adsorption onto core-shell tubular and vesicular structures of diphenylalanine/parylene

Abstract

All Science Journal Classification (ASJC) codes

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